Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer - PubMed

Review

Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer

B H Park et al. Curr Opin Oncol. 2001 Jan.

Abstract

Peroxisome proliferator-activated receptors are nuclear receptors that were isolated for their ability to modulate lipid metabolism. Similar to other members of the nuclear receptor family, peroxisome proliferator-activated receptors bind ligand as heterodimers and exert their effects via transcriptional regulation through their DNA binding domains. During the past decade, it has become clear that peroxisome proliferator-activated receptors also contribute to a variety of different biologic processes, including atherosclerosis, insulin resistance, and more recently, cancer. In this review, we discuss the evidence for the different peroxisome proliferator-activated receptors' roles in tumorigenesis and also their potential application for the treatment and prevention of neoplastic diseases.

Similar articles

• An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer.

  Gelman L, Fruchart JC, Auwerx J. Gelman L, et al. Cell Mol Life Sci. 1999 Jun;55(6-7):932-43. doi: 10.1007/s000180050345. Cell Mol Life Sci. 1999. PMID: 10412372 Free PMC article. Review.

• Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators.

  Corton JC, Anderson SP, Stauber A. Corton JC, et al. Annu Rev Pharmacol Toxicol. 2000;40:491-518. doi: 10.1146/annurev.pharmtox.40.1.491. Annu Rev Pharmacol Toxicol. 2000. PMID: 10836145 Review.

• Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model.

  Rivier M, Castiel I, Safonova I, Ailhaud G, Michel S. Rivier M, et al. J Invest Dermatol. 2000 Apr;114(4):681-7. doi: 10.1046/j.1523-1747.2000.00939.x. J Invest Dermatol. 2000. PMID: 10733673

• Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?

  Melnick RL. Melnick RL. Environ Health Perspect. 2001 May;109(5):437-42. doi: 10.1289/ehp.01109437. Environ Health Perspect. 2001. PMID: 11401753 Free PMC article. Review.

• Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism.

  Latruffe N, Vamecq J. Latruffe N, et al. Biochimie. 1997 Feb-Mar;79(2-3):81-94. doi: 10.1016/s0300-9084(97)81496-4. Biochimie. 1997. PMID: 9209701 Review.

Cited by

• Osteosarcoma development and stem cell differentiation.

  Tang N, Song WX, Luo J, Haydon RC, He TC. Tang N, et al. Clin Orthop Relat Res. 2008 Sep;466(9):2114-30. doi: 10.1007/s11999-008-0335-z. Epub 2008 Jun 18. Clin Orthop Relat Res. 2008. PMID: 18563507 Free PMC article. Review.

• Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.

  Pedchenko TV, Gonzalez AL, Wang D, DuBois RN, Massion PP. Pedchenko TV, et al. Am J Respir Cell Mol Biol. 2008 Dec;39(6):689-96. doi: 10.1165/rcmb.2007-0426OC. Epub 2008 Jun 19. Am J Respir Cell Mol Biol. 2008. PMID: 18566335 Free PMC article.

• 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages.

  Xu L, Shen S, Ma Y, Kim JK, Rodriguez-Agudo D, Heuman DM, Hylemon PB, Pandak WM, Ren S. Xu L, et al. Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E788-99. doi: 10.1152/ajpendo.00337.2011. Epub 2012 Jan 24. Am J Physiol Endocrinol Metab. 2012. PMID: 22275753 Free PMC article.

• Therapeutic Implications of PPARgamma in Human Osteosarcoma.

  Wagner ER, He BC, Chen L, Zuo GW, Zhang W, Shi Q, Luo Q, Luo X, Liu B, Luo J, Rastegar F, He CJ, Hu Y, Boody B, Luu HH, He TC, Deng ZL, Haydon RC. Wagner ER, et al. PPAR Res. 2010;2010:956427. doi: 10.1155/2010/956427. Epub 2010 Feb 16. PPAR Res. 2010. PMID: 20182546 Free PMC article.

• Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells.

  Zhu GH, Huang J, Bi Y, Su Y, Tang Y, He BC, He Y, Luo J, Wang Y, Chen L, Zuo GW, Jiang W, Luo Q, Shen J, Liu B, Zhang WL, Shi Q, Zhang BQ, Kang Q, Zhu J, Tian J, Luu HH, Haydon RC, Chen Y, He TC. Zhu GH, et al. Differentiation. 2009 Nov;78(4):195-204. doi: 10.1016/j.diff.2009.06.001. Epub 2009 Jun 27. Differentiation. 2009. PMID: 19560855 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wolters Kluwer

• Miscellaneous

  • NCI CPTAC Assay Portal