Genetics of type 1A diabetes - PubMed
Review
Genetics of type 1A diabetes
M J Redondo et al. Recent Prog Horm Res. 2001.
Abstract
Type 1A diabetes is an autoimmune disease with genetic and environmental factors contributing to its etiology. Twin studies, family studies, and animal models have helped to elucidate the genetics of autoimmune diabetes. Most of the genetic susceptibility is accounted for by human leukocyte antigen (HLA) alleles. The most-common susceptibility haplotypes are DQA1*0301-DQB1*0302 and DQA1*0501-DQB1*0201. Less-common haplotypes such as DQA1*0401-DQB1*0402 and DQA1*0101-DQB1*0501 are associated with high risk for diabetes; however, large study populations are needed to analyze their effect. The DQA1*0102-DQB1*0602 haplotype is associated with diabetes resistance. DR molecules, such as DRB1*1401, confer protection from diabetes. Monozygotic twins of patients with type 1A diabetes have a diabetes risk higher than that for HLA-identical ordinary siblings, suggesting that non-HLA genes contribute to diabetes risk. Polymorphisms in the regulatory region of the insulin gene (designated IDDM2), polymorphisms in cytotoxic T lymphocyte antigen-4 (CTLA-4) gene (IDDM12), and other genes are likely to contribute to diabetes risk and susceptibility in some individuals. In selected families, major diabetogenes (e.g., IDDM17, autoimmune regulator gene (AIRE)) are likely to be of importance. Other factors--either noninherited genes (i.e., somatic mutations and T-cell receptor or immunoglobulin rearrangements) or environment--may have a role in progression to diabetes. This is suggested by the finding that the risk for monozygotic twins of patients with type 1A diabetes is not 100 percent. Studying the genetics of type 1A diabetes will allow us to better define this disease, to improve our ability to identify individuals at risk, and to predict the risk of associated disorders.
Similar articles
-
Hu CY, Allen M, Chuang LM, Lin BJ, Gyllensten U. Hu CY, et al. Hum Immunol. 1993 Oct;38(2):105-14. doi: 10.1016/0198-8859(93)90526-7. Hum Immunol. 1993. PMID: 8106265
-
Petrone A, Bugawan TL, Mesturino CA, Nisticò L, Galgani A, Giorgi G, Cascino I, Erlich HA, Di Mario U, Buzzetti R. Petrone A, et al. Tissue Antigens. 2001 Dec;58(6):385-94. doi: 10.1034/j.1399-0039.2001.580607.x. Tissue Antigens. 2001. PMID: 11929589
-
Sanjeevi CB, Lybrand TP, Landin-Olsson M, Kockum I, Dahlquist G, Hagopian WA, Palmer JP, Lernmark A. Sanjeevi CB, et al. Tissue Antigens. 1994 Aug;44(2):110-9. doi: 10.1111/j.1399-0039.1994.tb02366.x. Tissue Antigens. 1994. PMID: 7817375
-
Genetic markers for insulin-dependent diabetes mellitus in Japanese.
Awata T, Kanazawa Y. Awata T, et al. Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S83-7. doi: 10.1016/0168-8227(94)90232-1. Diabetes Res Clin Pract. 1994. PMID: 7859639 Review.
-
Genetics of autoimmune diabetes mellitus.
Cerná M. Cerná M. Wien Med Wochenschr. 2008;158(1-2):2-12. doi: 10.1007/s10354-007-0448-0. Wien Med Wochenschr. 2008. PMID: 18286244 Review.
Cited by
-
Stem Cells in the Exocrine Pancreas during Homeostasis, Injury, and Cancer.
Lodestijn SC, van Neerven SM, Vermeulen L, Bijlsma MF. Lodestijn SC, et al. Cancers (Basel). 2021 Jun 30;13(13):3295. doi: 10.3390/cancers13133295. Cancers (Basel). 2021. PMID: 34209288 Free PMC article. Review.
-
Type 1 diabetes and periodontal disease: a literature review.
Reddy M, Gopalkrishna P. Reddy M, et al. Can J Dent Hyg. 2022 Feb 1;56(1):22-30. eCollection 2022 Feb. Can J Dent Hyg. 2022. PMID: 35401764 Free PMC article. Review.
-
Soluble factors secreted by T cells promote β-cell proliferation.
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Dirice E, et al. Diabetes. 2014 Jan;63(1):188-202. doi: 10.2337/db13-0204. Epub 2013 Oct 2. Diabetes. 2014. PMID: 24089508 Free PMC article.
-
Carlsson A, Kockum I, Lindblad B, Engleson L, Nilsson A, Forsander G, Karlsson AK, Kernell A, Ludvigsson J, Marcus C, Zachrisson I, Ivarsson SA, Lernmark A; Swedish Better Diabetes Diagnosis Study Group. Carlsson A, et al. Int J Obes (Lond). 2012 May;36(5):718-24. doi: 10.1038/ijo.2011.122. Epub 2011 Jun 28. Int J Obes (Lond). 2012. PMID: 21712811 Free PMC article.
-
Pane JA, Webster NL, Coulson BS. Pane JA, et al. PLoS Pathog. 2014 Mar 27;10(3):e1003998. doi: 10.1371/journal.ppat.1003998. eCollection 2014 Mar. PLoS Pathog. 2014. PMID: 24676425 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Research Materials