The splice of life: alternative splicing and neurological disease - PubMed

Review

The splice of life: alternative splicing and neurological disease

B K Dredge et al. Nat Rev Neurosci. 2001 Jan.

Abstract

Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases. Neuron-specific proteins involved in RNA splicing and metabolism are also affected in several neurological disorders. These findings have begun to bridge what we know about the mechanisms regulating neuron-specific splicing and our understanding of neural function and disease.

Similar articles

• Essential nucleotides direct neuron-specific splicing of gamma 2 pre-mRNA.

  Zhang L, Ashiya M, Sherman TG, Grabowski PJ. Zhang L, et al. RNA. 1996 Jul;2(7):682-98. RNA. 1996. PMID: 8756411 Free PMC article.

• CLIP identifies Nova-regulated RNA networks in the brain.

  Ule J, Jensen KB, Ruggiu M, Mele A, Ule A, Darnell RB. Ule J, et al. Science. 2003 Nov 14;302(5648):1212-5. doi: 10.1126/science.1090095. Science. 2003. PMID: 14615540

• Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA.

  Bourgeois CF, Lejeune F, Stévenin J. Bourgeois CF, et al. Prog Nucleic Acid Res Mol Biol. 2004;78:37-88. doi: 10.1016/S0079-6603(04)78002-2. Prog Nucleic Acid Res Mol Biol. 2004. PMID: 15210328 Review.

• Neuronal regulation of alternative pre-mRNA splicing.

  Li Q, Lee JA, Black DL. Li Q, et al. Nat Rev Neurosci. 2007 Nov;8(11):819-31. doi: 10.1038/nrn2237. Nat Rev Neurosci. 2007. PMID: 17895907 Review.

Cited by

• The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.

  Sena RM, Twiss JL, Gardiner AS, Dell'Orco M, Linsenbardt DN, Perrone-Bizzozero NI. Sena RM, et al. Molecules. 2021 May 11;26(10):2836. doi: 10.3390/molecules26102836. Molecules. 2021. PMID: 34064652 Free PMC article.

• Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels.

  Castiglioni AJ, Raingo J, Lipscombe D. Castiglioni AJ, et al. J Physiol. 2006 Oct 1;576(Pt 1):119-34. doi: 10.1113/jphysiol.2006.115030. Epub 2006 Jul 20. J Physiol. 2006. PMID: 16857708 Free PMC article.

• Genome-wide analysis of transcription factors in hippocampal tissue of cerebral palsy rats after acupuncture treatment.

  Zhou Y, Bahetibieke N, Fang L, Wu Y, Wang M, Niu X, Zeng B, Zhou G. Zhou Y, et al. Am J Transl Res. 2023 Apr 15;15(4):2622-2633. eCollection 2023. Am J Transl Res. 2023. PMID: 37193171 Free PMC article.

• Alternative splicing and cancer: a systematic review.

  Zhang Y, Qian J, Gu C, Yang Y. Zhang Y, et al. Signal Transduct Target Ther. 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. Signal Transduct Target Ther. 2021. PMID: 33623018 Free PMC article.

• Ligand-induced sequestering of branchpoint sequence allows conditional control of splicing.

  Kim DS, Gusti V, Dery KJ, Gaur RK. Kim DS, et al. BMC Mol Biol. 2008 Feb 12;9:23. doi: 10.1186/1471-2199-9-23. BMC Mol Biol. 2008. PMID: 18267036 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information