Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice - PubMed

Affiliations

• PMID: 11431570
• DOI: 10.1126/science.1059365

Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice

V Mack et al. Science. 2001.

Abstract

Plasticity of mature hippocampal CA1 synapses is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.

Similar articles

• A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A.

  Jensen V, Kaiser KM, Borchardt T, Adelmann G, Rozov A, Burnashev N, Brix C, Frotscher M, Andersen P, Hvalby Ø, Sakmann B, Seeburg PH, Sprengel R. Jensen V, et al. J Physiol. 2003 Dec 15;553(Pt 3):843-56. doi: 10.1113/jphysiol.2003.053637. Epub 2003 Oct 10. J Physiol. 2003. PMID: 14555717 Free PMC article.

• Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses.

  Kakegawa W, Tsuzuki K, Yoshida Y, Kameyama K, Ozawa S. Kakegawa W, et al. Eur J Neurosci. 2004 Jul;20(1):101-10. doi: 10.1111/j.1460-9568.2004.03461.x. Eur J Neurosci. 2004. PMID: 15245483

• Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.

  Shemer I, Holmgren C, Min R, Fülöp L, Zilberter M, Sousa KM, Farkas T, Härtig W, Penke B, Burnashev N, Tanila H, Zilberter Y, Harkany T. Shemer I, et al. Eur J Neurosci. 2006 Apr;23(8):2035-47. doi: 10.1111/j.1460-9568.2006.04733.x. Eur J Neurosci. 2006. PMID: 16630051

• Role of AMPA receptors in synaptic plasticity.

  Sprengel R. Sprengel R. Cell Tissue Res. 2006 Nov;326(2):447-55. doi: 10.1007/s00441-006-0275-4. Epub 2006 Aug 1. Cell Tissue Res. 2006. PMID: 16896950 Review.

• Role of syntaxin 4 in activity-dependent exocytosis and synaptic plasticity in hippocampal neurons.

  Mohanasundaram P, Shanmugam MM. Mohanasundaram P, et al. Sci Signal. 2010 Oct 19;3(144):jc7. doi: 10.1126/scisignal.3144jc7. Sci Signal. 2010. PMID: 20959521 Review.

Cited by

• Central amygdala GluA1 facilitates associative learning of opioid reward.

  Cai YQ, Wang W, Hou YY, Zhang Z, Xie J, Pan ZZ. Cai YQ, et al. J Neurosci. 2013 Jan 23;33(4):1577-88. doi: 10.1523/JNEUROSCI.1749-12.2013. J Neurosci. 2013. PMID: 23345231 Free PMC article.

• JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1.

  Lin CH, Lee EH. Lin CH, et al. J Neurosci. 2012 Feb 1;32(5):1826-46. doi: 10.1523/JNEUROSCI.3380-11.2012. J Neurosci. 2012. PMID: 22302822 Free PMC article.

• Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.

  Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. Klug JR, et al. PLoS One. 2012;7(9):e45323. doi: 10.1371/journal.pone.0045323. Epub 2012 Sep 21. PLoS One. 2012. PMID: 23028932 Free PMC article.

• Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus.

  Selcher JC, Xu W, Hanson JE, Malenka RC, Madison DV. Selcher JC, et al. Brain Res. 2012 Jan 30;1435:8-14. doi: 10.1016/j.brainres.2011.11.029. Epub 2011 Nov 19. Brain Res. 2012. PMID: 22197030 Free PMC article.

• Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion.

  Plitt MH, Kaganovsky K, Südhof TC, Giocomo LM. Plitt MH, et al. bioRxiv [Preprint]. 2023 Nov 21:2023.11.20.567978. doi: 10.1101/2023.11.20.567978. bioRxiv. 2023. PMID: 38045362 Free PMC article. Preprint.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal