Genomic structures and population histories of linguistically distinct tribal groups of India - PubMed

Affiliations

• PMID: 11702215
• DOI: 10.1007/s004390100577

Genomic structures and population histories of linguistically distinct tribal groups of India

S Roychoudhury et al. Hum Genet. 2001 Sep.

Abstract

There are various conflicting hypotheses regarding the origins of the tribal groups of India, who belong to three major language groups--Austro-Asiatic, Dravidian and Tibeto-Burman. To test some of the major hypotheses we designed a genetic study in which we sampled tribal populations belonging to all the three language groups. We used a set of autosomal DNA markers, mtDNA restriction-site polymorphisms (RSPs) and mtDNA hypervariable segment-1 (HVS-1) sequence polymorphisms in this study. Using the unlinked autosomal markers we found that there is a fair correspondence between linguistic and genomic affinities among the Indian tribal groups. We reconstructed mtDNA RSP haplotypes and found that there is extensive haplotype sharing among all tribal populations. However, there is very little sharing of mtDNA HVS-1 sequences across populations, and none across language groups. Haplogroup M is ubiquitous, and the subcluster U2i of haplogroup U occurs in a high frequency. Our analyses of haplogroup and HVS-1 sequence data provides evidence in support of the hypothesis that the Austro-Asiatic speakers are the most ancient inhabitants of India. Our data also support the earlier finding that some of the western Eurasian haplogroups found in India may have been present in India prior to the entry of Aryan speakers. However, we do not find compelling evidence to support the theory that haplogroup M was brought into India on an "out of Africa" wave of migration through a southern exit route from Ethiopia. On the contrary, our data raise the possibility that this haplogroup arose in India and was later carried to East Africa from India.

Similar articles

• Phylogeography of mitochondrial DNA and Y-chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India.

  Sahoo S, Kashyap VK. Sahoo S, et al. Am J Phys Anthropol. 2006 Sep;131(1):84-97. doi: 10.1002/ajpa.20399. Am J Phys Anthropol. 2006. PMID: 16485297

• Mitochondrial DNA analysis reveals diverse histories of tribal populations from India.

  Cordaux R, Saha N, Bentley GR, Aunger R, Sirajuddin SM, Stoneking M. Cordaux R, et al. Eur J Hum Genet. 2003 Mar;11(3):253-64. doi: 10.1038/sj.ejhg.5200949. Eur J Hum Genet. 2003. PMID: 12678055

• Genetic variation in India.

  Papiha SS. Papiha SS. Hum Biol. 1996 Oct;68(5):607-28. Hum Biol. 1996. PMID: 8908794 Review.

• Distribution of four founding mtDNA haplogroups among Native North Americans.

  Lorenz JG, Smith DG. Lorenz JG, et al. Am J Phys Anthropol. 1996 Nov;101(3):307-23. doi: 10.1002/(SICI)1096-8644(199611)101:3<307::AID-AJPA1>3.0.CO;2-W. Am J Phys Anthropol. 1996. PMID: 8922178 Review.

Cited by

• Comparative analyses of genetic risk prediction methods reveal extreme diversity of genetic predisposition to nonalcoholic fatty liver disease (NAFLD) among ethnic populations of India.

  Chatterjee A, Basu A, Chowdhury A, Das K, Sarkar-Roy N, Majumder PP, Basu P. Chatterjee A, et al. J Genet. 2015 Mar;94(1):105-13. doi: 10.1007/s12041-015-0494-0. J Genet. 2015. PMID: 25846882

• A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians.

  Vimaleswaran KS, Radha V, Ramya K, Babu HN, Savitha N, Roopa V, Monalisa D, Deepa R, Ghosh S, Majumder PP, Rao MR, Mohan V. Vimaleswaran KS, et al. Hum Genet. 2008 Jul;123(6):599-605. doi: 10.1007/s00439-008-0506-8. Epub 2008 May 9. Hum Genet. 2008. PMID: 18465144

• Genetic variation and population structure of interleukin genes among seven ethnic populations from Karnataka, India.

  Raj SM, Govindaraju DR, Chakraborty R. Raj SM, et al. J Genet. 2007 Dec;86(3):189-94. doi: 10.1007/s12041-007-0026-7. J Genet. 2007. PMID: 18305338

• Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations.

  Thangaraj K, Sridhar V, Kivisild T, Reddy AG, Chaubey G, Singh VK, Kaur S, Agarawal P, Rai A, Gupta J, Mallick CB, Kumar N, Velavan TP, Suganthan R, Udaykumar D, Kumar R, Mishra R, Khan A, Annapurna C, Singh L. Thangaraj K, et al. Hum Genet. 2005 May;116(6):507-17. doi: 10.1007/s00439-005-1271-6. Epub 2005 Mar 17. Hum Genet. 2005. PMID: 15772853

• The earliest settlers' antiquity and evolutionary history of Indian populations: evidence from M2 mtDNA lineage.

  Kumar S, Padmanabham PB, Ravuri RR, Uttaravalli K, Koneru P, Mukherjee PA, Das B, Kotal M, Xaviour D, Saheb SY, Rao VR. Kumar S, et al. BMC Evol Biol. 2008 Aug 11;8:230. doi: 10.1186/1471-2148-8-230. BMC Evol Biol. 2008. PMID: 18691441 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • The Lens - Patent Citations Database