The JNK signal transduction pathway - PubMed

Review

The JNK signal transduction pathway

Claire R Weston et al. Curr Opin Genet Dev. 2002 Feb.

Abstract

The c-Jun NH(2)-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family of mitogen-activated protein (MAP) kinases. Recent studies have led to progress towards understanding the physiological function of the JNK signaling pathway, including the analysis of the phenotype of knockout mice. An important role for JNK in the non-canonical Wnt-signaling pathway has been established. Insight into the role of scaffold proteins that may assemble functional JNK modules has been achieved. In addition, a small molecule pharmacological inhibitor of JNK has been described and it is likely that this drug will facilitate future studies of JNK function.

Similar articles

• The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs).

  Barr RK, Bogoyevitch MA. Barr RK, et al. Int J Biochem Cell Biol. 2001 Nov;33(11):1047-63. doi: 10.1016/s1357-2725(01)00093-0. Int J Biochem Cell Biol. 2001. PMID: 11551821 Review.

• Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.

  Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T. Ikeda A, et al. J Biochem. 2001 Dec;130(6):773-81. doi: 10.1093/oxfordjournals.jbchem.a003048. J Biochem. 2001. PMID: 11726277

• Activation mechanism and physiological roles of stress-activated protein kinase/c-Jun NH2-terminal kinase in mammalian cells.

  Nishina H, Nakagawa K, Azuma N, Katada T. Nishina H, et al. J Biol Regul Homeost Agents. 2003 Oct-Dec;17(4):295-302. J Biol Regul Homeost Agents. 2003. PMID: 15065757 Review.

• The JNK signal transduction pathway.

  Weston CR, Davis RJ. Weston CR, et al. Curr Opin Cell Biol. 2007 Apr;19(2):142-9. doi: 10.1016/j.ceb.2007.02.001. Epub 2007 Feb 15. Curr Opin Cell Biol. 2007. PMID: 17303404 Review.

• Physiological roles of SAPK/JNK signaling pathway.

  Nishina H, Wada T, Katada T. Nishina H, et al. J Biochem. 2004 Aug;136(2):123-6. doi: 10.1093/jb/mvh117. J Biochem. 2004. PMID: 15496581 Review.

Cited by

• c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development.

  An MJ, Lee HM, Kim CH, Shin GS, Jo AR, Kim JY, Kim MJ, Kim J, Park J, Hwangbo Y, Kim J, Kim JW. An MJ, et al. Genes Genomics. 2023 Apr;45(4):429-435. doi: 10.1007/s13258-022-01342-w. Epub 2022 Nov 24. Genes Genomics. 2023. PMID: 36434388

• Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression.

  Tai YL, Tung LH, Lin YC, Lu PJ, Chu PY, Wang MY, Huang WP, Chen KC, Lee H, Shen TL. Tai YL, et al. PLoS One. 2016 Sep 22;11(9):e0163617. doi: 10.1371/journal.pone.0163617. eCollection 2016. PLoS One. 2016. PMID: 27658202 Free PMC article.

• Osteopontin Deficiency Alters Biliary Homeostasis and Protects against Gallstone Formation.

  Lin J, Lu M, Shao WQ, Chen ZY, Zhu WW, Lu L, Jia HL, Cai D, Qin LX, Chen JH. Lin J, et al. Sci Rep. 2016 Aug 3;6:30215. doi: 10.1038/srep30215. Sci Rep. 2016. PMID: 27484115 Free PMC article.

• Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development.

  Wang J, Tai G. Wang J, et al. Target Oncol. 2016 Dec;11(6):723-738. doi: 10.1007/s11523-016-0446-5. Target Oncol. 2016. PMID: 27392951 Review.

• JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo.

  Song Z, Tong C, Liang J, Dockendorff A, Huang C, Augenlicht LH, Yang W. Song Z, et al. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19. Eur J Pharmacol. 2007. PMID: 17292881 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal