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The relationship between FV Leiden and pulmonary embolism - PubMed

Review

doi: 10.1186/rr180. Epub 2001 Nov 19.

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Review

The relationship between FV Leiden and pulmonary embolism

W Craig Hooper et al. Respir Res. 2002.

Abstract

Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a 'milder' genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.

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References

    1. Anderson FA, Wheeler B, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, Forcier A, Dalen JE. A population based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. Arch Intern Med. 1991;151:933–938. doi: 10.1001/archinte.151.5.933. - DOI - PubMed
    1. De Stefano V, Chiusolo P, Paciaroni K, Leone G. Epidemiology of factor V Leiden: clinical implications. Seminar Thromb Hemost. 1998;24:367–379. - PubMed
    1. Price DT, Ridker PM. Factor V Leiden mutation and the risks for thromboembolic disease: A clinical perspective. Ann Intern Med. 1997;127:895–903. - PubMed
    1. Greengard JS, Sun X, Xu X, Fernandez JA, Griffin JH, Evatt B. Activated protein C resistance caused by Arg506Gln mutation in Va. Lancet. 1994;343:1361–1362. doi: 10.1016/S0140-6736(94)92497-X. - DOI - PubMed
    1. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Driven RJ, de Rhonde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64–67. doi: 10.1038/369064a0. - DOI - PubMed

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