Order and disorder: the role of extracellular matrix in epithelial cancer - PubMed
Review
Order and disorder: the role of extracellular matrix in epithelial cancer
Derek Radisky et al. Cancer Invest. 2002.
No abstract available
Figures
Architecture of the basement membrane and cell surface connections. Basement membrane is composed of interconnected networks of collagen IV, laminin, nidogen/entactin, and proteoglycans such as perlecan. These connect to the cell through cell surface receptors such as integrins and dystroglycan. These, in turn, connect to the actin cytoskeleton through cytoplasmic adapter protein complexes.
Components of the basement membrane. Presented in diagrammatic form to relative scale (scale bar = 50 nm).
Components of E-cadherin-mediated adherens junctions. E-cadherin is a cell surface molecule composed of five repeating motifs that contain calcium-binding domains. In the presence of extracellular calcium, E-cadherin molecules homodimerize and then associate with E-cadherin dimers on adjacent cells in a zipper-like mechanism. This process is coincident with association with actin filaments through cytoplasmic adapters including the catenins and α-actinin.
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