An expanding universe of noncoding RNAs - PubMed

Affiliations

• PMID: 12016301
• DOI: 10.1126/science.1072249

An expanding universe of noncoding RNAs

Gisela Storz. Science. 2002.

Abstract

Noncoding RNAs (ncRNAs) have been found to have roles in a great variety of processes, including transcriptional regulation, chromosome replication, RNA processing and modification, messenger RNA stability and translation, and even protein degradation and translocation. Recent studies indicate that ncRNAs are far more abundant and important than initially imagined. These findings raise several fundamental questions: How many ncRNAs are encoded by a genome? Given the absence of a diagnostic open reading frame, how can these genes be identified? How can all the functions of ncRNAs be elucidated?

Similar articles

• Noncoding RNA transcripts.

  Szymański M, Barciszewska MZ, Zywicki M, Barciszewski J. Szymański M, et al. J Appl Genet. 2003;44(1):1-19. J Appl Genet. 2003. PMID: 12590177 Review.

• The expanding universe of noncoding RNAs.

  Hannon GJ, Rivas FV, Murchison EP, Steitz JA. Hannon GJ, et al. Cold Spring Harb Symp Quant Biol. 2006;71:551-64. doi: 10.1101/sqb.2006.71.064. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381339 Review.

• Life without RNAi: noncoding RNAs and their functions in Saccharomyces cerevisiae.

  Harrison BR, Yazgan O, Krebs JE. Harrison BR, et al. Biochem Cell Biol. 2009 Oct;87(5):767-79. doi: 10.1139/O09-043. Biochem Cell Biol. 2009. PMID: 19898526 Review.

• Controlling mRNA stability and translation with small, noncoding RNAs.

  Storz G, Opdyke JA, Zhang A. Storz G, et al. Curr Opin Microbiol. 2004 Apr;7(2):140-4. doi: 10.1016/j.mib.2004.02.015. Curr Opin Microbiol. 2004. PMID: 15063850 Review.

• Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level.

  Papenfort K, Vogel J. Papenfort K, et al. Res Microbiol. 2009 May;160(4):278-87. doi: 10.1016/j.resmic.2009.03.004. Epub 2009 Apr 12. Res Microbiol. 2009. PMID: 19366629 Review.

Cited by

• Epigenetics and Inflammation in Diabetic Nephropathy.

  Shao BY, Zhang SF, Li HD, Meng XM, Chen HY. Shao BY, et al. Front Physiol. 2021 May 5;12:649587. doi: 10.3389/fphys.2021.649587. eCollection 2021. Front Physiol. 2021. PMID: 34025445 Free PMC article. Review.

• LncRNApred: Classification of Long Non-Coding RNAs and Protein-Coding Transcripts by the Ensemble Algorithm with a New Hybrid Feature.

  Pian C, Zhang G, Chen Z, Chen Y, Zhang J, Yang T, Zhang L. Pian C, et al. PLoS One. 2016 May 26;11(5):e0154567. doi: 10.1371/journal.pone.0154567. eCollection 2016. PLoS One. 2016. PMID: 27228152 Free PMC article.

• Epigenetic control on cell fate choice in neural stem cells.

  Hu XL, Wang Y, Shen Q. Hu XL, et al. Protein Cell. 2012 Apr;3(4):278-90. doi: 10.1007/s13238-012-2916-6. Epub 2012 May 2. Protein Cell. 2012. PMID: 22549586 Free PMC article. Review.

• A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3' termini.

  Scacchetti A, Shields EJ, Trigg NA, Lee GS, Wilusz JE, Conine CC, Bonasio R. Scacchetti A, et al. Mol Cell. 2024 Oct 3;84(19):3843-3859.e8. doi: 10.1016/j.molcel.2024.07.008. Epub 2024 Aug 2. Mol Cell. 2024. PMID: 39096899

• Can Clustal-style progressive pairwise alignment of multiple sequences be used in RNA secondary structure prediction?

  Bellamy-Royds AB, Turcotte M. Bellamy-Royds AB, et al. BMC Bioinformatics. 2007 Jun 8;8:190. doi: 10.1186/1471-2105-8-190. BMC Bioinformatics. 2007. PMID: 17559658 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database