Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation - PubMed

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• PMID: 12089510
• DOI: 10.1038/ni817

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

Valentino Parravicini et al. Nat Immunol. 2002 Aug.

Abstract

Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases.

Comment in

• Uncovering new complexities in mast cell signaling.

  Nadler MJ, Kinet JP. Nadler MJ, et al. Nat Immunol. 2002 Aug;3(8):707-8. doi: 10.1038/ni0802-707. Nat Immunol. 2002. PMID: 12145654 No abstract available.

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