pubmed.ncbi.nlm.nih.gov

Mean versus individual hormonal profiles in the menstrual cycle - PubMed

Mean versus individual hormonal profiles in the menstrual cycle

María Elena Alliende. Fertil Steril. 2002 Jul.

Free article

Abstract

Objective: To evaluate hormonal profiles of normal menstrual cycles.

Design: Prospective, descriptive study of a case series.

Setting: University-based natural family planning center.

Patient(s): Twenty-five natural family planning users for three or more cycles (n = 78). These women were healthy, contraception-free, parous, with regular ovulatory cycles.

Intervention(s): Immunoassays for estrone glucuronide, LH, and pregnanediol glucuronide were done in daily timed and measured samples of early morning urine.

Main outcome measure(s): Estrone glucuronide, LH, and pregnanediol glucuronide levels were measured during the menstrual cycle.

Result(s): All cycles showed an ovulatory pattern configuring classic hormonal mean curves. Most (77%) differed from the mean curve pattern. All had estrone glucuronide peaks, LH peaks, and pregnanediol glucuronide increases. Estrone glucuronide and LH peaks were not always clear; some lasted more than 1 day (long peak: estrone glucuronide 19%, LH 9%) or fluctuated (double peak: estrone glucuronide 4%, LH 6%; small LH peak: 19%). There were also prepeak estrone glucuronide surges, and pre- and postpeak LH surges. Pregnanediol glucuronide increased more clearly (6% fluctuated 1 day). Some women had repeated cycles with long estrone glucuronide peaks (16%) and fluctuations in LH surge (44%).

Conclusion(s): Normal menstrual cycle hormonal profiles generally differ from mean curves, which are usually considered standard.

PubMed Disclaimer

Cited by

Frozen-thawed embryo transfer in modified natural cycles: a retrospective analysis of pregnancy outcomes in ovulatory women with vs. without spontaneous luteinizing hormone surge.
Ye H, Shi L, Quan X, Xue X, Qian Y, Tian H, Xue S, Sun L. Ye H, et al. BMC Pregnancy Childbirth. 2022 Nov 4;22(1):814. doi: 10.1186/s12884-022-05161-5. BMC Pregnancy Childbirth. 2022. PMID: 36333653 Free PMC article.
Types of ovarian activity in women and their significance: the continuum (a reinterpretation of early findings).
Brown JB. Brown JB. Hum Reprod Update. 2011 Mar-Apr;17(2):141-58. doi: 10.1093/humupd/dmq040. Epub 2010 Oct 5. Hum Reprod Update. 2011. PMID: 20923873 Free PMC article. Review.
Ovarian follicular development during the use of oral contraception: a review.
Baerwald AR, Pierson RA. Baerwald AR, et al. J Obstet Gynaecol Can. 2004 Jan;26(1):19-24. doi: 10.1016/s1701-2163(16)30692-2. J Obstet Gynaecol Can. 2004. PMID: 14715122 Free PMC article. Review.
The Use of Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity.
Blackwell LF, Cooke DG, Brown S. Blackwell LF, et al. Front Public Health. 2018 May 31;6:153. doi: 10.3389/fpubh.2018.00153. eCollection 2018. Front Public Health. 2018. PMID: 29904626 Free PMC article. Review.
"Luteal Analgesia": Progesterone Dissociates Pain Intensity and Unpleasantness by Influencing Emotion Regulation Networks.
Vincent K, Stagg CJ, Warnaby CE, Moore J, Kennedy S, Tracey I. Vincent K, et al. Front Endocrinol (Lausanne). 2018 Jul 23;9:413. doi: 10.3389/fendo.2018.00413. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30083136 Free PMC article.

Mean versus individual hormonal profiles in the menstrual cycle - PubMed