Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis - PubMed

Affiliations

• PMID: 12138120
• DOI: 10.1074/jbc.M206083200

Free article

Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis

Morihiro Matsuda et al. J Biol Chem. 2002.

Free article

Abstract

Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity and vascular disease is still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, and that hypoadiponectinemia is associated to ischemic heart disease. In current the study, we investigated the in vivo role of adiponectin on the neointimal thickening after artery injury using adiponectin-deficient mice and adiponectin-producing adenovirus. Adiponectin-deficient mice showed severe neointimal thickening and increased proliferation of vascular smooth muscle cells in mechanically injured arteries. Adenovirus-mediated supplement of adiponectin attenuated neointimal proliferation. In cultured smooth muscle cells, adiponectin attenuated DNA synthesis induced by growth factors including platelet-derived growth factor, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), basic fibroblast growth factor, and EGF and cell proliferation and migration induced by HB-EGF. In cultured endothelial cells, adiponectin attenuated HB-EGF expression stimulated by tumor necrosis factor alpha. The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty.

Similar articles

• Periadventitial adipose tissue plays a critical role in vascular remodeling.

  Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y, Tabata Y, Saito Y, Nagai R, Sata M. Takaoka M, et al. Circ Res. 2009 Oct 23;105(9):906-11. doi: 10.1161/CIRCRESAHA.109.199653. Epub 2009 Sep 17. Circ Res. 2009. PMID: 19762682

• Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.

  Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, Nakamura T, Shimomura I, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Arita Y, et al. Circulation. 2002 Jun 18;105(24):2893-8. doi: 10.1161/01.cir.0000018622.84402.ff. Circulation. 2002. PMID: 12070119

• Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries.

  Igura T, Kawata S, Miyagawa J, Inui Y, Tamura S, Fukuda K, Isozaki K, Yamamori K, Taniguchi N, Higashiyama S, Matsuzawa Y. Igura T, et al. Arterioscler Thromb Vasc Biol. 1996 Dec;16(12):1524-31. doi: 10.1161/01.atv.16.12.1524. Arterioscler Thromb Vasc Biol. 1996. PMID: 8977458

• Importance of adipocytokines in obesity-related diseases.

  Matsuzawa Y, Shimomura I, Kihara S, Funahashi T. Matsuzawa Y, et al. Horm Res. 2003;60 Suppl 3:56-9. doi: 10.1159/000074502. Horm Res. 2003. PMID: 14671398 Review.

• Obesity, adiponectin and vascular inflammatory disease.

  Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. Ouchi N, et al. Curr Opin Lipidol. 2003 Dec;14(6):561-6. doi: 10.1097/00041433-200312000-00003. Curr Opin Lipidol. 2003. PMID: 14624132 Review.

Cited by

• Cardiovascular risk associated with the metabolic syndrome.

  Lindsay RS, Howard BV. Lindsay RS, et al. Curr Diab Rep. 2004 Feb;4(1):63-8. doi: 10.1007/s11892-004-0013-9. Curr Diab Rep. 2004. PMID: 14764282 Review.

• Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctions.

  Santini F, Marsili A, Mammoli C, Valeriano R, Scartabelli G, Pelosini C, Giannetti M, Centoni R, Vitti P, Pinchera A. Santini F, et al. J Endocrinol Invest. 2004 Feb;27(2):RC5-7. doi: 10.1007/BF03346252. J Endocrinol Invest. 2004. PMID: 15129802

• Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.

  Ishikawa M, Kitayama J, Yamauchi T, Kadowaki T, Maki T, Miyato H, Yamashita H, Nagawa H. Ishikawa M, et al. Cancer Sci. 2007 Jul;98(7):1120-7. doi: 10.1111/j.1349-7006.2007.00486.x. Epub 2007 Apr 23. Cancer Sci. 2007. PMID: 17459059 Free PMC article.

• Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention [corrected] in patients with coronary artery disease.

  Inami N, Nomura S, Shimazu T, Manabe K, Kimura Y, Iwasaka T. Inami N, et al. J Thromb Thrombolysis. 2007 Dec;24(3):267-73. doi: 10.1007/s11239-007-0042-8. Epub 2007 May 8. J Thromb Thrombolysis. 2007. PMID: 17486299

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)