Network meta-analysis for indirect treatment comparisons - PubMed

Affiliations

• PMID: 12210616
• DOI: 10.1002/sim.1201

Network meta-analysis for indirect treatment comparisons

Thomas Lumley. Stat Med. 2002.

Abstract

I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta-analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency ('incoherence') in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta-analysis of treatments for acute myocardial infarction.

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