HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors - PubMed

Affiliations

• PMID: 12368910
• DOI: 10.1038/ni845

Comparative Study

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

Stephen A Migueles et al. Nat Immunol. 2002 Nov.

Abstract

It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.

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