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Herpes viruses hedge their bets - PubMed

  • ️Tue Jan 01 2002

Herpes viruses hedge their bets

Michael P H Stumpf et al. Proc Natl Acad Sci U S A. 2002.

Abstract

Static latency is the hallmark of all herpes viruses. The varicella zoster virus, for instance, causes varicella (chickenpox), and after a latent phase of between 5 and 40 years, it can give rise to herpes zoster (shingles). This latency and the subsequent reactivation has intrigued and puzzled virologists. Although several factors have been suggested, it is unknown what triggers reactivation. However, latency can be explained with a simple evolutionary model. Here, we demonstrate that a simple, yet efficient, bet-hedging strategy might have evolved in a number of viruses, especially those belonging to the herpes virus family and most importantly in varicella zoster virus. We show that the evolution of latency can be explained by the population dynamics of infectious diseases in fluctuating host populations.

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Figures

Fig 1.
Fig 1.

Growth rates versus latency τ. We plotted average values of λτ/λ0 for three fluctuating environments. (a) rg = 3.65, rb = 1/rg ≃ 0.274, and P = 0.5. Different symbols represent the cases for which (i) m = 0.975, c1 = 0.9, and c2 = 0.1 (⧫), (ii) m = 0.9, c1 = 0.9, and c2 = 0.1 (*), and (iii) m = 0.975, c1 = 0.99, and c2 = 0.01 (▪). (b) rg = 2.58, rb = 0.387, and other parameters are as described in a. (c) rg = 6.32, rb = 0.158, and other parameters are as described in a. (d) We have assumed the same values for rg and rb as described in a, but now bad periods are more likely than good periods with P = 0.4.

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References

    1. Ahmed R., Morrison, L. A. & Knipe, D. M. (1996) in Fundamental Virology, eds. Fields, B. N., Knipe, D. M. & Howley, P. M. (Lippincott, Philadelphia), pp. 207–237.
    1. Johnson R. T., (1998) Viral Infections of the Nervous System (Lippincott, Philadelphia).
    1. Perng C. C., Jones, C., Ciacci-Zanilla, J., Stone, M., Henderson, G., Yukht, A., Slanina, S. M., Hofman, F. M., Ghiasi, H., Nesburn, A. B. & Wechslev, S. L. (2000) Science 287, 1500-1504. - PubMed
    1. Daheshia M., Feldman, L. T. & Rouse, B. T. (1998) Curr. Opin. Microbiol. 1, 430-435. - PubMed
    1. Kennedy P. G. E., Grinfeld, E. & Gow, J. W. (1998) Proc. Natl. Acad. Sci. USA 95, 4658-4662. - PMC - PubMed

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