Fruit flies and humans respond differently to retrotransposons - PubMed

Review

Fruit flies and humans respond differently to retrotransposons

Thomas H Eickbush et al. Curr Opin Genet Dev. 2002 Dec.

Abstract

Retrotransposable element insertions are 20 times more numerous per unit length of DNA in the large human genome compared to the small Drosophila genome. Whereas all Drosophila elements are subject to constant turnover (recent insertion and elimination by selection), this has not generally been the case for human retrotransposons. We suggest that a difference in recombination adopted by these organisms in response to the deleterious effects of interspersed repeated DNA can explain in part this fundamental difference between the evolutionary dynamics of fruit fly and human retrotransposons.

Similar articles

• Retrotransposable elements and human disease.

  Callinan PA, Batzer MA. Callinan PA, et al. Genome Dyn. 2006;1:104-115. doi: 10.1159/000092503. Genome Dyn. 2006. PMID: 18724056 Review.

• Mobile elements: drivers of genome evolution.

  Kazazian HH Jr. Kazazian HH Jr. Science. 2004 Mar 12;303(5664):1626-32. doi: 10.1126/science.1089670. Science. 2004. PMID: 15016989 Review.

• A single lineage of r2 retrotransposable elements is an active, evolutionarily stable component of the Drosophila rDNA locus.

  Lathe WC 3rd, Eickbush TH. Lathe WC 3rd, et al. Mol Biol Evol. 1997 Dec;14(12):1232-41. doi: 10.1093/oxfordjournals.molbev.a025732. Mol Biol Evol. 1997. PMID: 9402733

• Diversity and clustered distribution of retrotransposable elements in the compact genome of the pufferfish Tetraodon nigroviridis.

  Fischer C, Bouneau L, Coutanceau JP, Weissenbach J, Ozouf-Costaz C, Volff JN. Fischer C, et al. Cytogenet Genome Res. 2005;110(1-4):522-36. doi: 10.1159/000084985. Cytogenet Genome Res. 2005. PMID: 16093705

• Telomere-Specialized Retroelements in Drosophila: Adaptive Symbionts of the Genome, Neutral, or in Conflict?

  Markova DN, Christensen SM, Betrán E. Markova DN, et al. Bioessays. 2020 Jan;42(1):e1900154. doi: 10.1002/bies.201900154. Epub 2019 Dec 9. Bioessays. 2020. PMID: 31815300 Review.

Cited by

• The evolution and diversity of DNA transposons in the genome of the Lizard Anolis carolinensis.

  Novick PA, Smith JD, Floumanhaft M, Ray DA, Boissinot S. Novick PA, et al. Genome Biol Evol. 2011;3:1-14. doi: 10.1093/gbe/evq080. Epub 2010 Dec 2. Genome Biol Evol. 2011. PMID: 21127169 Free PMC article.

• Multiple and diversified transposon lineages contribute to early and recent bivalve genome evolution.

  Martelossi J, Nicolini F, Subacchi S, Pasquale D, Ghiselli F, Luchetti A. Martelossi J, et al. BMC Biol. 2023 Jun 26;21(1):145. doi: 10.1186/s12915-023-01632-z. BMC Biol. 2023. PMID: 37365567 Free PMC article.

• Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories.

  Arkhipova IR. Arkhipova IR. Mob DNA. 2017 Dec 6;8:19. doi: 10.1186/s13100-017-0103-2. eCollection 2017. Mob DNA. 2017. PMID: 29225705 Free PMC article. Review.

• Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi.

  Zhang LY, Yang YF, Niu DK. Zhang LY, et al. J Mol Evol. 2010 Dec;71(5-6):364-73. doi: 10.1007/s00239-010-9391-6. Epub 2010 Sep 23. J Mol Evol. 2010. PMID: 20862581

• Chromosomal location of retrotransposable REX 1 in the genomes in five Prochilodus (Teleostei: Characiformes.

  Voltolin TA, Mendonça BB, Ferreira DC, Senhorini JA, Foresti F, Porto-Foresti F. Voltolin TA, et al. Mob Genet Elements. 2013 Jul 1;3(4):e25846. doi: 10.4161/mge.25846. Epub 2013 Aug 2. Mob Genet Elements. 2013. PMID: 24195015 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Molecular Biology Databases

  • FlyBase