Multiplicity of gonadotropin-releasing hormone signaling: a comparative perspective - PubMed

Review

Multiplicity of gonadotropin-releasing hormone signaling: a comparative perspective

Christian Klausen et al. Prog Brain Res. 2002.

Abstract

GnRH regulation of GtH synthesis and release involves PKC- and Ca(2+)-dependent pathways. There are differential signaling mechanisms in different cells, tissues and species. Signaling mechanisms involved in GnRH-mediated GtH release appear to be more conserved compared to that of GnRH-induced GtH gene expression. This may in part be due to different 5' regulatory regions on the GtH-subunit genes. Cell type specific expression of various signaling and/or exocytotic components may also be responsible for the observed differences in signaling between gonadotropes and somatotropes in the goldfish and tilapia pituitaries. However, this can not explain the observed differences in post receptor mechanisms for sGnRH and cGnRH-II in gonadotropes which is more likely to result from the existence of GnRH receptor subtypes. Support for this hypothesis is also provided by observations on mechanisms of autocrine/paracrine regulation of ovarian function by sGnRH and cGnRH-II in the goldfish ovary in which GnRH antagonists only block GnRH stimulation of oocyte meiosis and do not affect inhibitory effects of sGnRH. It should be easier to explain observed variations concerning GnRH-induced responses as more information becomes available on different types of GnRH receptors, and their distribution and function in mammals and non-mammalian vertebrates.

Similar articles

• Functional evidence regarding receptor subtypes mediating the actions of native gonadotropin-releasing hormones (GnRH) in goldfish, Carassius auratus.

  Murthy CK, Peter RE. Murthy CK, et al. Gen Comp Endocrinol. 1994 Apr;94(1):78-91. doi: 10.1006/gcen.1994.1062. Gen Comp Endocrinol. 1994. PMID: 8045371

• mRNA expression of gonadotropin-releasing hormones (GnRHs) and GnRH receptor in goldfish.

  Yu KL, He ML, Chik CC, Lin XW, Chang JP, Peter RE. Yu KL, et al. Gen Comp Endocrinol. 1998 Dec;112(3):303-11. doi: 10.1006/gcen.1998.7137. Gen Comp Endocrinol. 1998. PMID: 9843636

• Mechanism of GnRH receptor signaling: combinatorial cross-talk of Ca2+ and protein kinase C.

  Naor Z, Harris D, Shacham S. Naor Z, et al. Front Neuroendocrinol. 1998 Jan;19(1):1-19. doi: 10.1006/frne.1997.0162. Front Neuroendocrinol. 1998. PMID: 9465287 Review.

• The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor.

  Cheng KW, Leung PC. Cheng KW, et al. Can J Physiol Pharmacol. 2000 Dec;78(12):1029-52. Can J Physiol Pharmacol. 2000. PMID: 11149380 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Miscellaneous

  • NCI CPTAC Assay Portal