Alpha4 integrins as therapeutic targets in autoimmune disease - PubMed

• PMID: 12510047
• DOI: 10.1056/NEJMe020157

Editorial

Alpha4 integrins as therapeutic targets in autoimmune disease

Ulrich H von Andrian et al. N Engl J Med. 2003.

Comment on

• A controlled trial of natalizumab for relapsing multiple sclerosis.

  Miller DH, Khan OA, Sheremata WA, Blumhardt LD, Rice GP, Libonati MA, Willmer-Hulme AJ, Dalton CM, Miszkiel KA, O'Connor PW; International Natalizumab Multiple Sclerosis Trial Group. Miller DH, et al. N Engl J Med. 2003 Jan 2;348(1):15-23. doi: 10.1056/NEJMoa020696. N Engl J Med. 2003. PMID: 12510038 Clinical Trial.

• Natalizumab for active Crohn's disease.

  Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnálek P, Zádorová Z, Palmer T, Donoghue S; Natalizumab Pan-European Study Group. Ghosh S, et al. N Engl J Med. 2003 Jan 2;348(1):24-32. doi: 10.1056/NEJMoa020732. N Engl J Med. 2003. PMID: 12510039 Clinical Trial.

Similar articles

• Natalizumab for relapsing multiple sclerosis.

  Tenser RB. Tenser RB. N Engl J Med. 2006 Jun 1;354(22):2387-9; author reply 2387-9. doi: 10.1056/NEJMc060894. N Engl J Med. 2006. PMID: 16738278 No abstract available.

• Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases?

  Davenport RJ, Munday JR. Davenport RJ, et al. Drug Discov Today. 2007 Jul;12(13-14):569-76. doi: 10.1016/j.drudis.2007.05.001. Epub 2007 Jun 26. Drug Discov Today. 2007. PMID: 17631252 Review.

• Iatrogenic immunosuppression with biologics in MS: expecting the unexpected?

  Stüve O, Wiendl H. Stüve O, et al. Neurology. 2009 Oct 27;73(17):1346-7. doi: 10.1212/WNL.0b013e3181beed38. Epub 2009 Sep 23. Neurology. 2009. PMID: 19776376 No abstract available.

• Asymptomatic reactivation of JC virus in patients treated with natalizumab.

  Gorelik L, Goelz S, Sandrock AW. Gorelik L, et al. N Engl J Med. 2009 Dec 17;361(25):2487-8; author reply 2489-90. doi: 10.1056/NEJMc0909622. N Engl J Med. 2009. PMID: 20018972 No abstract available.

• A balancing act--making the right choices in anti-inflammatory drug development.

  Elices MJ. Elices MJ. Curr Opin Investig Drugs. 2007 May;8(5):362-3. Curr Opin Investig Drugs. 2007. PMID: 17520864 Review. No abstract available.

Cited by

• A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

  Arrode-Brusés G, Goode D, Kleinbeck K, Wilk J, Frank I, Byrareddy S, Arthos J, Grasperge B, Blanchard J, Zydowsky T, Gettie A, Martinelli E. Arrode-Brusés G, et al. PLoS Pathog. 2016 Jun 27;12(6):e1005720. doi: 10.1371/journal.ppat.1005720. eCollection 2016 Jun. PLoS Pathog. 2016. PMID: 27348748 Free PMC article.

• Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis.

  Offner H, Sinha S, Wang C, Burrows GG, Vandenbark AA. Offner H, et al. Rev Neurosci. 2008;19(4-5):327-39. doi: 10.1515/revneuro.2008.19.4-5.327. Rev Neurosci. 2008. PMID: 19145988 Free PMC article. Review.

• Magnetic resonance imaging of human brain macrophage infiltration.

  Petry KG, Boiziau C, Dousset V, Brochet B. Petry KG, et al. Neurotherapeutics. 2007 Jul;4(3):434-42. doi: 10.1016/j.nurt.2007.05.005. Neurotherapeutics. 2007. PMID: 17599709 Free PMC article. Review.

• Intraepithelial lymphocytes: to serve and protect.

  Sheridan BS, Lefrançois L. Sheridan BS, et al. Curr Gastroenterol Rep. 2010 Dec;12(6):513-21. doi: 10.1007/s11894-010-0148-6. Curr Gastroenterol Rep. 2010. PMID: 20890736 Free PMC article. Review.

• Expression of selected integrins and selectins in bullous pemphigoid.

  Zebrowska A, Sysa-Jedrzejowska A, Wagrowska-Danilewicz M, Joss-Wichman E, Erkiert-Polguj A, Waszczykowska E. Zebrowska A, et al. Mediators Inflamm. 2007;2007:31051. doi: 10.1155/2007/31051. Epub 2007 Apr 2. Mediators Inflamm. 2007. PMID: 17515951 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information