Too much Csx/Nkx2-5 is as bad as too little? - PubMed

Editorial

Too much Csx/Nkx2-5 is as bad as too little?

Hiroshi Akazawa et al. J Mol Cell Cardiol. 2003 Mar.

Comment on

• Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes.

  Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S. Kasahara H, et al. J Mol Cell Cardiol. 2003 Mar;35(3):243-56. doi: 10.1016/s0022-2828(03)00002-6. J Mol Cell Cardiol. 2003. PMID: 12676539

Similar articles

• A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

  Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. Tanaka M, et al. Cold Spring Harb Symp Quant Biol. 2002;67:317-25. doi: 10.1101/sqb.2002.67.317. Cold Spring Harb Symp Quant Biol. 2002. PMID: 12858555 No abstract available.

• Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart.

  Toko H, Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I. Toko H, et al. J Biol Chem. 2002 Jul 5;277(27):24735-43. doi: 10.1074/jbc.M107669200. Epub 2002 Mar 11. J Biol Chem. 2002. PMID: 11889119

• Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice.

  Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, Hiroi Y, Oka T, Hayashi D, Hirai H, Kudoh S, Toko H, Kawamura K, Nagai R, Yazaki Y, Komuro I. Takimoto E, et al. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1074-9. doi: 10.1006/bbrc.2000.2561. Biochem Biophys Res Commun. 2000. PMID: 10772952

• Homeodomain factor Nkx2-5 in heart development and disease.

  Harvey RP, Lai D, Elliott D, Biben C, Solloway M, Prall O, Stennard F, Schindeler A, Groves N, Lavulo L, Hyun C, Yeoh T, Costa M, Furtado M, Kirk E. Harvey RP, et al. Cold Spring Harb Symp Quant Biol. 2002;67:107-14. doi: 10.1101/sqb.2002.67.107. Cold Spring Harb Symp Quant Biol. 2002. PMID: 12858530 Review. No abstract available.

• Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases.

  Akazawa H, Komuro I. Akazawa H, et al. Pharmacol Ther. 2005 Aug;107(2):252-68. doi: 10.1016/j.pharmthera.2005.03.005. Pharmacol Ther. 2005. PMID: 15925411 Review.

Cited by

• An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.

  George V, Colombo S, Targoff KL. George V, et al. Dev Biol. 2015 Apr 1;400(1):10-22. doi: 10.1016/j.ydbio.2014.12.019. Epub 2014 Dec 20. Dev Biol. 2015. PMID: 25536398 Free PMC article.

• Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene.

  Fuchs C, Gawlas S, Heher P, Nikouli S, Paar H, Ivankovic M, Schultheis M, Klammer J, Gottschamel T, Capetanaki Y, Weitzer G. Fuchs C, et al. Biol Open. 2016 Jan 19;5(2):140-53. doi: 10.1242/bio.014993. Biol Open. 2016. PMID: 26787680 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Research Materials

  • NCI CPTC Antibody Characterization Program