pubmed.ncbi.nlm.nih.gov

Aetiology: Koch's postulates fulfilled for SARS virus - PubMed

  • ️Wed Jan 01 2003

Aetiology: Koch's postulates fulfilled for SARS virus

Ron A M Fouchier et al. Nature. 2003.

Abstract

Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease.

Supplementary information: The online version of this article (doi:10.1038/423240a) contains supplementary material, which is available to authorized users.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. SARS-associated coronavirus and associated lesions in macaque lungs.

a, Virus particles re-isolated from nasal swabs of infected macaques display typical coronavirus morphology. b, Diffuse alveolar damage in the lung; alveoli are flooded with highly proteinaceous fluid (arrowhead) that stains dark pink. c, Several syncytia (arrowheads) are present in the lumen of a bronchiole and surrounding alveoli. Original magnifications: a, ×200,000; b, ×150; c, ×100.

Similar articles

  • Virology: SARS virus infection of cats and ferrets.

    Martina BE, Haagmans BL, Kuiken T, Fouchier RA, Rimmelzwaan GF, Van Amerongen G, Peiris JS, Lim W, Osterhaus AD. Martina BE, et al. Nature. 2003 Oct 30;425(6961):915. doi: 10.1038/425915a. Nature. 2003. PMID: 14586458 Free PMC article.

  • Macaque model for severe acute respiratory syndrome.

    Rowe T, Gao G, Hogan RJ, Crystal RG, Voss TG, Grant RL, Bell P, Kobinger GP, Wivel NA, Wilson JM. Rowe T, et al. J Virol. 2004 Oct;78(20):11401-4. doi: 10.1128/JVI.78.20.11401-11404.2004. J Virol. 2004. PMID: 15452262 Free PMC article.

  • The SARS-CoV ferret model in an infection-challenge study.

    Chu YK, Ali GD, Jia F, Li Q, Kelvin D, Couch RC, Harrod KS, Hutt JA, Cameron C, Weiss SR, Jonsson CB. Chu YK, et al. Virology. 2008 Apr 25;374(1):151-63. doi: 10.1016/j.virol.2007.12.032. Epub 2008 Jan 29. Virology. 2008. PMID: 18234270 Free PMC article.

  • Pathogenesis of severe acute respiratory syndrome.

    Lau YL, Peiris JS. Lau YL, et al. Curr Opin Immunol. 2005 Aug;17(4):404-10. doi: 10.1016/j.coi.2005.05.009. Curr Opin Immunol. 2005. PMID: 15950449 Free PMC article. Review.

  • The aetiology of SARS: Koch's postulates fulfilled.

    Osterhaus AD, Fouchier RA, Kuiken T. Osterhaus AD, et al. Philos Trans R Soc Lond B Biol Sci. 2004 Jul 29;359(1447):1081-2. doi: 10.1098/rstb.2004.1489. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15306393 Free PMC article. Review.

Cited by

References

    1. Rivers TM. J. Bacteriol. 1937;33:1–12. - PMC - PubMed
    1. Poutanen, S. M. et al. N. Engl. J. Med. (in the press).
    1. Drosten, C. et al. N. Engl. J. Med. (in the press).
    1. Ksiazek, T. G. et al. N. Engl. J. Med. (in the press).
    1. Peiris JSM, et al. Lancet. 2003;361:1319–1325. doi: 10.1016/S0140-6736(03)13077-2. - DOI - PMC - PubMed

MeSH terms