Fanconi anaemia proteins: major roles in cell protection against oxidative damage - PubMed

Review

Fanconi anaemia proteins: major roles in cell protection against oxidative damage

Giovanni Pagano et al. Bioessays. 2003 Jun.

Abstract

Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P-450 reductase and with glutathione S-transferase, and of FANCG with cytochrome P-450 2E1, as well as redox-dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co-ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6-12).

Similar articles

• Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.

  Hussain S, Witt E, Huber PA, Medhurst AL, Ashworth A, Mathew CG. Hussain S, et al. Hum Mol Genet. 2003 Oct 1;12(19):2503-10. doi: 10.1093/hmg/ddg266. Epub 2003 Aug 5. Hum Mol Genet. 2003. PMID: 12915460

• Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis.

  Huber PA, Medhurst AL, Youssoufian H, Mathew CG. Huber PA, et al. Biochem Biophys Res Commun. 2000 Feb 5;268(1):73-7. doi: 10.1006/bbrc.1999.2055. Biochem Biophys Res Commun. 2000. PMID: 10652215

• Molecular biology of Fanconi anaemia--an old problem, a new insight.

  Ahmad SI, Hanaoka F, Kirk SH. Ahmad SI, et al. Bioessays. 2002 May;24(5):439-48. doi: 10.1002/bies.10082. Bioessays. 2002. PMID: 12001267 Review.

• FANCE: the link between Fanconi anaemia complex assembly and activity.

  Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ. Pace P, et al. EMBO J. 2002 Jul 1;21(13):3414-23. doi: 10.1093/emboj/cdf355. EMBO J. 2002. PMID: 12093742 Free PMC article.

• The interplay of Fanconi anemia proteins in the DNA damage response.

  Wang X, D'Andrea AD. Wang X, et al. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1063-9. doi: 10.1016/j.dnarep.2004.04.005. DNA Repair (Amst). 2004. PMID: 15279794 Review.

Cited by

• DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.

  Rozelle AL, Cheun Y, Vilas CK, Koag MC, Lee S. Rozelle AL, et al. Nat Commun. 2021 Mar 26;12(1):1897. doi: 10.1038/s41467-021-22273-2. Nat Commun. 2021. PMID: 33772030 Free PMC article.

• Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.

  Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE. Mukhopadhyay SS, et al. J Cell Biol. 2006 Oct 23;175(2):225-35. doi: 10.1083/jcb.200607061. J Cell Biol. 2006. PMID: 17060495 Free PMC article.

• Genetic instability syndromes with progeroid features.

  Neveling K, Bechtold A, Hoehn H. Neveling K, et al. Z Gerontol Geriatr. 2007 Oct;40(5):339-48. doi: 10.1007/s00391-007-0483-x. Z Gerontol Geriatr. 2007. PMID: 17943237 Review.

• Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.

  Thompson LH, Hinz JM. Thompson LH, et al. Mutat Res. 2009 Jul 31;668(1-2):54-72. doi: 10.1016/j.mrfmmm.2009.02.003. Epub 2009 Feb 21. Mutat Res. 2009. PMID: 19622404 Free PMC article. Review.

• Molecular cross-talk among chromosome fragility syndromes.

  Surrallés J, Jackson SP, Jasin M, Kastan MB, West SC, Joenje H. Surrallés J, et al. Genes Dev. 2004 Jun 15;18(12):1359-70. doi: 10.1101/gad.1216304. Genes Dev. 2004. PMID: 15198978 Free PMC article. No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Miscellaneous

  • NCI CPTAC Assay Portal