Human immunodeficiency virus infection of cells arrested in the cell cycle - PubMed

Human immunodeficiency virus infection of cells arrested in the cell cycle

P Lewis et al. EMBO J. 1992 Aug.

Erratum in

• EMBO J 1992 Nov;11(11):4249

Abstract

Cell proliferation is necessary for proviral integration and productive infection of most retroviruses. Nevertheless, the human immunodeficiency virus (HIV) can infect non-dividing macrophages. This ability to grow in non-dividing cells is not specific to macrophages because, as we show here, CD4+ HeLa cells arrested at stage G2 of the cell cycle can be infected by HIV-1. Proliferation is necessary for these same cells to be infected by a murine retrovirus, MuLV. HIV-1 integrates into the arrested cell DNA and produces viral RNA and protein in a pattern similar to that in normal cells. In addition, our data suggest that the ability to infect non-dividing cells is due to one of the HIV-1 core virion proteins. HIV infection of non-dividing cells distinguishes lentiviruses from other retroviruses and is likely to be important in the natural history of HIV infection.

Similar articles

• A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.

  Bukrinsky MI, Haggerty S, Dempsey MP, Sharova N, Adzhubel A, Spitz L, Lewis P, Goldfarb D, Emerman M, Stevenson M. Bukrinsky MI, et al. Nature. 1993 Oct 14;365(6447):666-9. doi: 10.1038/365666a0. Nature. 1993. PMID: 8105392 Free PMC article.

• Cell cycle dependence of foamy retrovirus infection.

  Bieniasz PD, Weiss RA, McClure MO. Bieniasz PD, et al. J Virol. 1995 Nov;69(11):7295-9. doi: 10.1128/JVI.69.11.7295-7299.1995. J Virol. 1995. PMID: 7474157 Free PMC article.

• Functional exchange of an oncoretrovirus and a lentivirus matrix protein.

  Deminie CA, Emerman M. Deminie CA, et al. J Virol. 1994 Jul;68(7):4442-9. doi: 10.1128/JVI.68.7.4442-4449.1994. J Virol. 1994. PMID: 8207817 Free PMC article.

• HIV-1 replication.

  Freed EO. Freed EO. Somat Cell Mol Genet. 2001 Nov;26(1-6):13-33. doi: 10.1023/a:1021070512287. Somat Cell Mol Genet. 2001. PMID: 12465460 Review.

Cited by

• Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.

  De Iaco A, Luban J. De Iaco A, et al. Retrovirology. 2011 Dec 6;8:98. doi: 10.1186/1742-4690-8-98. Retrovirology. 2011. PMID: 22145813 Free PMC article.

• Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities.

  Lin P, Lin Y, Lennon DP, Correa D, Schluchter M, Caplan AI. Lin P, et al. Stem Cells Transl Med. 2012 Dec;1(12):886-97. doi: 10.5966/sctm.2012-0086. Epub 2012 Nov 29. Stem Cells Transl Med. 2012. PMID: 23283550 Free PMC article.

• Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.

  Wang D, de la Fuente C, Deng L, Wang L, Zilberman I, Eadie C, Healey M, Stein D, Denny T, Harrison LE, Meijer L, Kashanchi F. Wang D, et al. J Virol. 2001 Aug;75(16):7266-79. doi: 10.1128/JVI.75.16.7266-7279.2001. J Virol. 2001. PMID: 11461999 Free PMC article.

• Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

  Trobridge G, Russell DW. Trobridge G, et al. J Virol. 2004 Mar;78(5):2327-35. doi: 10.1128/jvi.78.5.2327-2335.2004. J Virol. 2004. PMID: 14963129 Free PMC article.

• Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein.

  Silvers RM, Smith JA, Schowalter M, Litwin S, Liang Z, Geary K, Daniel R. Silvers RM, et al. Hum Gene Ther. 2010 Mar;21(3):337-49. doi: 10.1089/hum.2009.134. Hum Gene Ther. 2010. PMID: 19877879 Free PMC article.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Nature Publishing Group
  • PubMed Central
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program