Sumatriptan is a potent vasoconstrictor of human dural arteries via a 5-HT1-like receptor - PubMed

Comparative Study

Sumatriptan is a potent vasoconstrictor of human dural arteries via a 5-HT1-like receptor

I Jansen et al. Cephalalgia. 1992 Aug.

Abstract

The action of sumatriptan, putatively a selective 5-HT1D or 5-HT1-like receptor agonist which is effective in the treatment of migraine, has been studied on fresh human dural (middle meningeal) arteries. In low concentrations (10(-8)-10(-7) M) it was found to be a significantly stronger vasoconstrictor of dural arteries compared to cerebral and temporal arteries. However, its potency was less than that of 5-HT. The sumatriptan-induced vasoconstriction was antagonized by methiothepin (10(-9)-10(-8) M), but not by ketanserin (10(-7) M). The observations suggest that the sumatriptan-induced contraction of the dural artery is mediated via activation of 5-HT1D or 5-HT1-like receptors, whereas it does not appear to activate the 5-HT2 receptors.

Comment in

• Sumatriptan.

  Welch K. Welch K. Cephalalgia. 1992 Aug;12(4):185. doi: 10.1046/j.1468-2982.1992.1204185.x. Cephalalgia. 1992. PMID: 1326400 No abstract available.

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