Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas - PubMed
. 1992 Dec;7(12):2549-53.
Affiliations
- PMID: 1334253
Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas
M F Di Renzo et al. Oncogene. 1992 Dec.
Abstract
The receptor for Hepatocyte Growth Factor is a transmembrane tyrosine kinase encoded by the c-MET oncogene. We have previously shown that the Met protein is expressed in several human epithelial tissues. The receptor is barely detectable, however, in normal thyroids and in specimens from patients affected by non-neoplastic thyroid diseases. Now we report that the expression of the Met/HGF receptor is increased a hundred fold in 22 out of 41 human carcinomas derived from the thyroid follicular epithelium. A comprehensive analysis of 15 cases showed that the overexpressing carcinomas belong to histotype variants correlated with negative prognosis and in all but one case there were evidences of locally advanced disease and/or distant metastases. The 11 benign adenomas and the 5 medullary carcinomas tested were negative. Western blot analysis with monoclonal antibodies directed against either the intracellular or the extracellular receptor domains failed to reveal major structural alterations. Southern blot analysis also demonstrated that the c-MET gene was not amplified nor rearranged. These data suggest a role for the overexpression of c-MET oncogene in the pathogenesis and progression of thyroid tumors derived from the follicular epithelium.
Similar articles
-
Expression of the Met/HGF receptor in normal and neoplastic human tissues.
Di Renzo MF, Narsimhan RP, Olivero M, Bretti S, Giordano S, Medico E, Gaglia P, Zara P, Comoglio PM. Di Renzo MF, et al. Oncogene. 1991 Nov;6(11):1997-2003. Oncogene. 1991. PMID: 1719465
-
Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM. Naldini L, et al. Oncogene. 1991 Apr;6(4):501-4. Oncogene. 1991. PMID: 1827664
-
Transformation of thyroid epithelium is associated with loss of c-kit receptor.
Natali PG, Berlingieri MT, Nicotra MR, Fusco A, Santoro E, Bigotti A, Vecchio G. Natali PG, et al. Cancer Res. 1995 Apr 15;55(8):1787-91. Cancer Res. 1995. PMID: 7536131
-
The hepatocyte growth factor and its receptor.
Galimi F, Brizzi MF, Comoglio PM. Galimi F, et al. Stem Cells. 1993 Jul;11 Suppl 2:22-30. doi: 10.1002/stem.5530110805. Stem Cells. 1993. PMID: 8401259 Review.
Cited by
-
Olivero M, Rizzo M, Madeddu R, Casadio C, Pennacchietti S, Nicotra MR, Prat M, Maggi G, Arena N, Natali PG, Comoglio PM, Di Renzo MF. Olivero M, et al. Br J Cancer. 1996 Dec;74(12):1862-8. doi: 10.1038/bjc.1996.646. Br J Cancer. 1996. PMID: 8980383 Free PMC article.
-
Co-expression of hepatocyte growth factor and its receptor in human prostate cancer.
Kurimoto S, Moriyama N, Horie S, Sakai M, Kameyama S, Akimoto Y, Hirano H, Kawabe K. Kurimoto S, et al. Histochem J. 1998 Jan;30(1):27-32. doi: 10.1023/a:1003262412346. Histochem J. 1998. PMID: 9539204
-
Matsumoto K, Date K, Shimura H, Nakamura T. Matsumoto K, et al. Jpn J Cancer Res. 1996 Jul;87(7):702-10. doi: 10.1111/j.1349-7006.1996.tb00281.x. Jpn J Cancer Res. 1996. PMID: 8698619 Free PMC article.
-
An overview of the c-MET signaling pathway.
Organ SL, Tsao MS. Organ SL, et al. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7-S19. doi: 10.1177/1758834011422556. Ther Adv Med Oncol. 2011. PMID: 22128289 Free PMC article.
-
Sigurdardottir AG, Winter A, Sobkowicz A, Fragai M, Chirgadze D, Ascher DB, Blundell TL, Gherardi E. Sigurdardottir AG, et al. Chem Sci. 2015 Nov 1;6(11):6147-6157. doi: 10.1039/c5sc02155c. Epub 2015 Jul 31. Chem Sci. 2015. PMID: 30090230 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Miscellaneous