Association between schizophrenia and homozygosity at the dopamine D3 receptor gene - PubMed

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene

M A Crocq et al. J Med Genet. 1992 Dec.

Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

Comment in

• Homozygosity at the dopamine D3 receptor locus is not associated with schizophrenia.

  Laurent C, Savoye C, Samolyk D, Meloni R, Mallet J, Campion D, Martinez M, D'Amato T, Bastard C, Dollfus S. Laurent C, et al. J Med Genet. 1994 Mar;31(3):260. doi: 10.1136/jmg.31.3.260-a. J Med Genet. 1994. PMID: 8014983 Free PMC article. No abstract available.

• Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

  Morell RT. Morell RT. J Med Genet. 1993 Aug;30(8):708-9. doi: 10.1136/jmg.30.8.708-a. J Med Genet. 1993. PMID: 8411063 Free PMC article. No abstract available.

• Excess of homozygosity at the dopamine D3 receptor gene in schizophrenia not confirmed.

  Nöthen MM, Cichon S, Propping P, Fimmers R, Schwab SG, Wildenauer DB. Nöthen MM, et al. J Med Genet. 1993 Aug;30(8):708. doi: 10.1136/jmg.30.8.708. J Med Genet. 1993. PMID: 8411064 Free PMC article. No abstract available.

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