Long-term administration of tianeptine in depressed patients after alcohol withdrawal - PubMed
Affiliations
- PMID: 1389025
Clinical Trial
Long-term administration of tianeptine in depressed patients after alcohol withdrawal
R Malka et al. Br J Psychiatry Suppl. 1992 Feb.
Abstract
Alcohol interferes with the central metabolism of the catecholamines and especially with indolamines (5-HT). Thus, the use of an antidepressant such as tianeptine, whose main neurochemical effect is to increase the reuptake of 5-HT, seems to be particularly indicated for the continued treatment of depressed patients after alcohol withdrawal. This study evaluated the therapeutic efficacy and acceptability during long-term administration of tianeptine in depressed patients (major depressive episode or dysthymic disorder) in a multicentre trial, after withdrawal from alcohol abuse or dependence. The results relate to 130 depressed patients, who abstained from alcohol and received treatment for a year. Only one patient dropped-out because of side-effects, and medication was interrupted in 5% of subjects because of alcoholic relapses. Prescribed in the long term, tianeptine did not produce orthostatic hypotension, changes in bodyweight, or alterations in the ECG. All changes found in haematological and biochemical investigations suggested an improvement in patients' physical state. This, and other studies, indicate that tianeptine appears to have the potential to be a safe antidepressant, which might be particularly useful in those patients who are susceptible to the side-effects of psychotropic drugs.
Similar articles
-
Tianeptine: a review of its use in depressive disorders.
Wagstaff AJ, Ormrod D, Spencer CM. Wagstaff AJ, et al. CNS Drugs. 2001;15(3):231-59. doi: 10.2165/00023210-200115030-00006. CNS Drugs. 2001. PMID: 11463130 Review.
-
Long-term use of tianeptine in 380 depressed patients.
Lôo H, Ganry H, Dufour H, Guelfi JD, Malka R, Olié JP, Scharbach H, Tignol J, Marey C, Kamoun A. Lôo H, et al. Br J Psychiatry Suppl. 1992 Feb;(15):61-5. Br J Psychiatry Suppl. 1992. PMID: 1389024 Clinical Trial.
-
Daléry J, Dagens-Lafant V, De Bodinat C. Daléry J, et al. Encephale. 1997 Jan-Feb;23(1):56-64. Encephale. 1997. PMID: 9172969 Clinical Trial. French.
-
[Tolerability of tianeptine in 170 patients with depression treated during one year].
Lôo H, Ganry H, Marey C, Briole G, Castelnau D, Charbonnier JF, Dachary JM, Danion JM, Darcourt G, Capdeville C, et al. Lôo H, et al. Encephale. 1990 Nov-Dec;16(6):445-52. Encephale. 1990. PMID: 2101783 Clinical Trial. French.
-
Antidepressant and anxiolytic activities of tianeptine: an overview of clinical trials.
Defrance R, Marey C, Kamoun A. Defrance R, et al. Clin Neuropharmacol. 1988;11 Suppl 2:S74-82. Clin Neuropharmacol. 1988. PMID: 2902922 Review.
Cited by
-
Tianeptine: a review of its use in depressive disorders.
Wagstaff AJ, Ormrod D, Spencer CM. Wagstaff AJ, et al. CNS Drugs. 2001;15(3):231-59. doi: 10.2165/00023210-200115030-00006. CNS Drugs. 2001. PMID: 11463130 Review.
-
Role of the serotonergic system in alcohol dependence: from animal models to clinics.
Sari Y, Johnson VR, Weedman JM. Sari Y, et al. Prog Mol Biol Transl Sci. 2011;98:401-43. doi: 10.1016/B978-0-12-385506-0.00010-7. Prog Mol Biol Transl Sci. 2011. PMID: 21199778 Free PMC article. Review.
-
Alcohol, nicotine, caffeine, and mental disorders.
Crocq MA. Crocq MA. Dialogues Clin Neurosci. 2003 Jun;5(2):175-85. doi: 10.31887/DCNS.2003.5.2/macrocq. Dialogues Clin Neurosci. 2003. PMID: 22033899 Free PMC article.
-
Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.
Agabio R, Trogu E, Pani PP. Agabio R, et al. Cochrane Database Syst Rev. 2018 Apr 24;4(4):CD008581. doi: 10.1002/14651858.CD008581.pub2. Cochrane Database Syst Rev. 2018. PMID: 29688573 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical