A second-generation linkage map of the human genome - PubMed

Affiliations

• PMID: 1436057
• DOI: 10.1038/359794a0

A second-generation linkage map of the human genome

J Weissenbach et al. Nature. 1992.

Abstract

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.

Comment in

• Human genome project. Variation is now the theme.

  Goodfellow PN. Goodfellow PN. Nature. 1992 Oct 29;359(6398):777-8. doi: 10.1038/359777a0. Nature. 1992. PMID: 1359422 No abstract available.

Similar articles

• The 1993-94 Généthon human genetic linkage map.

  Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J. Gyapay G, et al. Nat Genet. 1994 Jun;7(2 Spec No):246-339. doi: 10.1038/ng0694supp-246. Nat Genet. 1994. PMID: 7545953

• A linkage map of microsatellite markers on the human X chromosome.

  Donnelly A, Kozman H, Gedeon AK, Webb S, Lynch M, Sutherland GR, Richards RI, Mulley JC. Donnelly A, et al. Genomics. 1994 Apr;20(3):363-70. doi: 10.1006/geno.1994.1189. Genomics. 1994. PMID: 8034308

• A comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group.

  [No authors listed] [No authors listed] Science. 1992 Oct 2;258(5079):67-86. Science. 1992. PMID: 1439770 Review.

• Dinucleotide repeat loci contribute highly informative genetic markers to the human chromosome 2 linkage map.

  Todd S, Sherman SL, Naylor SL. Todd S, et al. Genomics. 1993 Jun;16(3):612-8. doi: 10.1006/geno.1993.1238. Genomics. 1993. PMID: 8100800

• Progress towards completing the human linkage map.

  Kidd KK. Kidd KK. Curr Opin Genet Dev. 1991 Jun;1(1):99-104. doi: 10.1016/0959-437x(91)80049-r. Curr Opin Genet Dev. 1991. PMID: 1840885 Review.

Cited by

• Loss of heterozygosity in lobular carcinoma in situ of the breast.

  Lakhani SR, Collins N, Sloane JP, Stratton MR. Lakhani SR, et al. Clin Mol Pathol. 1995 Apr;48(2):M74-8. doi: 10.1136/mp.48.2.m74. Clin Mol Pathol. 1995. PMID: 16695985 Free PMC article.

• Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation.

  Hart TC, Hart PS, Michalec MD, Zhang Y, Marazita ML, Cooper M, Yassin OM, Nusier M, Walker S. Hart TC, et al. J Med Genet. 2000 Feb;37(2):95-101. doi: 10.1136/jmg.37.2.95. J Med Genet. 2000. PMID: 10662808 Free PMC article.

• Genomewide linkage searches for Mendelian disease loci can be efficiently conducted using high-density SNP genotyping arrays.

  Sellick GS, Longman C, Tolmie J, Newbury-Ecob R, Geenhalgh L, Hughes S, Whiteford M, Garrett C, Houlston RS. Sellick GS, et al. Nucleic Acids Res. 2004 Nov 23;32(20):e164. doi: 10.1093/nar/gnh163. Nucleic Acids Res. 2004. PMID: 15561999 Free PMC article.

• A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: indication for a role of a tumour suppressor gene other than Rb.

  O'Connor DP, Kay EW, Leader M, Murphy GM, Atkins GJ, Mabruk MJ. O'Connor DP, et al. Mol Pathol. 2001 Jun;54(3):165-9. doi: 10.1136/mp.54.3.165. Mol Pathol. 2001. PMID: 11376129 Free PMC article.

• Trisomy 17 detected in amniotic fluid cells but not in newborn infant.

  Butler MG, Neu RL, Mitchell K. Butler MG, et al. Am J Med Genet. 1996 Oct 28;65(3):247-8. doi: 10.1002/ajmg.1320650402. Am J Med Genet. 1996. PMID: 9240752 Free PMC article. No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • The Weizmann Institute of Science GeneCards and MalaCards databases