Nuclear and unclear functions of SUMO - PubMed

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• PMID: 14506472
• DOI: 10.1038/nrm1200

Review

Nuclear and unclear functions of SUMO

Jacob-S Seeler et al. Nat Rev Mol Cell Biol. 2003 Sep.

Abstract

Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.

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