Mouse placenta is a major hematopoietic organ - PubMed

Affiliations

• PMID: 14507780
• DOI: 10.1242/dev.00755

Mouse placenta is a major hematopoietic organ

Marcio Alvarez-Silva et al. Development. 2003 Nov.

Abstract

Placenta and yolk sac from 8- to 17-day-old (E8-E17) mouse embryos/fetuses were investigated for the presence of in vitro clonogenic progenitors. At E8-E9, the embryonic body from the umbilicus caudalwards was also analysed. Fetal liver was analysed beginning on E10. At E8, between five and nine somite pairs (sp), placenta, yolk sac and embryonic body yielded no progenitors. The first progenitors appeared at E8.5 at the stage of 15 sp in the yolk sac, 18 sp in the embryonic body, 20 sp in the placenta and only at E12 in the fetal liver (absent at E10, at E11 not determined). Progenitors with a high proliferation potential that could be replated for two months, as well as the whole range of myeloid progenitors, were found at all stages in all organs. However, the earliest of these progenitors (these yielding large, multilineage colonies) were 2-4 times more frequent in the placenta than in the yolk sac or fetal liver. In the fetal liver, late progenitors were more frequent and the cellularity increased steeply with developmental age. Thus, the fetal liver, which is a recognized site for amplification and commitment, has a very different hematopoietic developmental profile from placenta or yolk sac. Placentas were obtained from GFP transgenic embryos in which only the embryonic contribution expressed the transgene. 80% of the colonies derived from these placental cells were GFP+, and so originated from the fetal component of the placenta. These data point to the placenta as a major hematopoietic organ that is active during most of pregnancy.

Similar articles

• SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis.

  Martin R, Lahlil R, Damert A, Miquerol L, Nagy A, Keller G, Hoang T. Martin R, et al. Development. 2004 Feb;131(3):693-702. doi: 10.1242/dev.00968. Development. 2004. PMID: 14729577

• Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.

  Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Wang LC, et al. EMBO J. 1997 Jul 16;16(14):4374-83. doi: 10.1093/emboj/16.14.4374. EMBO J. 1997. PMID: 9250681 Free PMC article.

• The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.

  Mukouyama Y, Chiba N, Hara T, Okada H, Ito Y, Kanamaru R, Miyajima A, Satake M, Watanabe T. Mukouyama Y, et al. Dev Biol. 2000 Apr 1;220(1):27-36. doi: 10.1006/dbio.2000.9617. Dev Biol. 2000. PMID: 10720428

• Embryonic stem cells and transgenic mice in the study of hematopoiesis.

  Orkin SH. Orkin SH. Int J Dev Biol. 1998;42(7):927-34. Int J Dev Biol. 1998. PMID: 9853823 Review.

• Allantois and placenta as developmental sources of hematopoietic stem cells.

  Dieterlen-Lièvre F, Corbel C, Salaün J. Dieterlen-Lièvre F, et al. Int J Dev Biol. 2010;54(6-7):1079-87. doi: 10.1387/ijdb.093047fd. Int J Dev Biol. 2010. PMID: 20563985 Review.

Cited by

• Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development.

  Robin C, Bollerot K, Mendes S, Haak E, Crisan M, Cerisoli F, Lauw I, Kaimakis P, Jorna R, Vermeulen M, Kayser M, van der Linden R, Imanirad P, Verstegen M, Nawaz-Yousaf H, Papazian N, Steegers E, Cupedo T, Dzierzak E. Robin C, et al. Cell Stem Cell. 2009 Oct 2;5(4):385-95. doi: 10.1016/j.stem.2009.08.020. Cell Stem Cell. 2009. PMID: 19796619 Free PMC article.

• Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth.

  Pereyra S, Sosa C, Bertoni B, Sapiro R. Pereyra S, et al. BMC Med Genomics. 2019 Apr 1;12(1):53. doi: 10.1186/s12920-019-0498-3. BMC Med Genomics. 2019. PMID: 30935390 Free PMC article.

• Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo.

  Orelio C, Haak E, Peeters M, Dzierzak E. Orelio C, et al. Blood. 2008 Dec 15;112(13):4895-904. doi: 10.1182/blood-2007-12-123836. Epub 2008 Sep 19. Blood. 2008. PMID: 18805969 Free PMC article.

• The human placenta is a hematopoietic organ during the embryonic and fetal periods of development.

  Bárcena A, Kapidzic M, Muench MO, Gormley M, Scott MA, Weier JF, Ferlatte C, Fisher SJ. Bárcena A, et al. Dev Biol. 2009 Mar 1;327(1):24-33. doi: 10.1016/j.ydbio.2008.11.017. Epub 2008 Dec 3. Dev Biol. 2009. PMID: 19073167 Free PMC article. Retracted.

• Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay.

  Karimzadeh A, Varady ES, Scarfone VM, Chao C, Grathwohl K, Nguyen PU, Ghorbanian Y, Weissman IL, Serwold T, Inlay MA. Karimzadeh A, et al. Front Cell Dev Biol. 2021 Aug 25;9:734176. doi: 10.3389/fcell.2021.734176. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34513848 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)