Are prenyl groups on proteins sticky fingers or greasy handles? - PubMed

Comment

Are prenyl groups on proteins sticky fingers or greasy handles?

Anthony I Magee et al. Biochem J. 2003.

Abstract

This Commentary discusses the work of Dietrich et al. in this issue of the Biochemical Journal, which sheds new light on the biological roles of protein-bound prenyl groups by providing evidence that the alpha-subunit of the heterotrimeric G-protein transducin has a binding site for the geranylgeranyl group of the gamma-subunit.

Comment on

• Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.

  Dietrich A, Scheer A, Illenberger D, Kloog Y, Henis YI, Gierschik P. Dietrich A, et al. Biochem J. 2003 Dec 1;376(Pt 2):449-56. doi: 10.1042/BJ20030578. Biochem J. 2003. PMID: 12952523 Free PMC article.

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