Role of Cdk5 in neuronal signaling, plasticity, and drug abuse - PubMed

Affiliations

• PMID: 14673205
• DOI: 10.1159/000074620

Review

Role of Cdk5 in neuronal signaling, plasticity, and drug abuse

James A Bibb. Neurosignals. 2003 Sep-Oct.

Abstract

Functional and structural neuronal plasticity are mediated by a complex network of biochemical signal transduction pathways that control the strength of specific synapses and the formation of new synapses de novo. The neuronal protein kinase Cdk5 has been implicated as being involved in numerous aspects of both functional and structural plasticity through its regulation of signal transduction pathways. In this review the findings of a number of studies are summarized that have advanced our understanding of how Cdk5 may be involved in these processes. We focus on the modulation of protein phosphatase activity in both the hippocampus and basal ganglia, and review findings that indicate Cdk5 is likely to regulate neuronal plasticity in these brain regions. Studies showing involvement of Cdk5 in reward and motor-based plasticity, which are thought to underlie drug abuse, are discussed.

Similar articles

• Role of Cdk5 in drug abuse and plasticity.

  Benavides DR, Bibb JA. Benavides DR, et al. Ann N Y Acad Sci. 2004 Oct;1025:335-44. doi: 10.1196/annals.1316.041. Ann N Y Acad Sci. 2004. PMID: 15542734 Review.

• Identification of tyrosine hydroxylase as a physiological substrate for Cdk5.

  Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope BT, Fitzpatrick PF, Bibb JA. Kansy JW, et al. J Neurochem. 2004 Oct;91(2):374-84. doi: 10.1111/j.1471-4159.2004.02723.x. J Neurochem. 2004. PMID: 15447670 Free PMC article.

• Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions.

  Schuman EM, Murase S. Schuman EM, et al. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):749-56. doi: 10.1098/rstb.2002.1256. Philos Trans R Soc Lond B Biol Sci. 2003. PMID: 12740122 Free PMC article.

• Alternative roles for Cdk5 in learning and synaptic plasticity.

  Hawasli AH, Bibb JA. Hawasli AH, et al. Biotechnol J. 2007 Aug;2(8):941-8. doi: 10.1002/biot.200700093. Biotechnol J. 2007. PMID: 17597494 Review.

• Recent advances in understanding the roles of Cdk5 in synaptic plasticity.

  Lai KO, Ip NY. Lai KO, et al. Biochim Biophys Acta. 2009 Aug;1792(8):741-5. doi: 10.1016/j.bbadis.2009.05.001. Epub 2009 May 13. Biochim Biophys Acta. 2009. PMID: 19442718 Review.

Cited by

• Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.

  Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Taylor JR, et al. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4147-52. doi: 10.1073/pnas.0610288104. Epub 2007 Feb 23. Proc Natl Acad Sci U S A. 2007. PMID: 17360491 Free PMC article.

• Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.

  Eagle AL, Gajewski PA, Yang M, Kechner ME, Al Masraf BS, Kennedy PJ, Wang H, Mazei-Robison MS, Robison AJ. Eagle AL, et al. J Neurosci. 2015 Oct 7;35(40):13773-83. doi: 10.1523/JNEUROSCI.2083-15.2015. J Neurosci. 2015. PMID: 26446228 Free PMC article.

• Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.

  Ruegsegger GN, Toedebusch RG, Childs TE, Grigsby KB, Booth FW. Ruegsegger GN, et al. J Physiol. 2017 Jan 1;595(1):363-384. doi: 10.1113/JP272489. Epub 2016 Sep 15. J Physiol. 2017. PMID: 27461471 Free PMC article.

• Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn.

  Pollonini G, Gao V, Rabe A, Palminiello S, Albertini G, Alberini CM. Pollonini G, et al. Neuroscience. 2008 Sep 22;156(1):99-106. doi: 10.1016/j.neuroscience.2008.07.025. Epub 2008 Jul 25. Neuroscience. 2008. PMID: 18703118 Free PMC article.

• Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.

  Marlier Q, D'aes T, Verteneuil S, Vandenbosch R, Malgrange B. Marlier Q, et al. Cell Mol Life Sci. 2020 Nov;77(22):4553-4571. doi: 10.1007/s00018-020-03548-1. Epub 2020 May 31. Cell Mol Life Sci. 2020. PMID: 32476056 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • S. Karger AG, Basel, Switzerland

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information