Mitochondrial DNA sequence diversity in a sedentary population from Egypt - PubMed

Mitochondrial DNA sequence diversity in a sedentary population from Egypt

A Stevanovitch et al. Ann Hum Genet. 2004 Jan.

Abstract

The mitochondrial DNA (mtDNA) diversity of 58 individuals from Upper Egypt, more than half (34 individuals) from Gurna, whose population has an ancient cultural history, were studied by sequencing the control-region and screening diagnostic RFLP markers. This sedentary population presented similarities to the Ethiopian population by the L1 and L2 macrohaplogroup frequency (20.6%), by the West Eurasian component (defined by haplogroups H to K and T to X) and particularly by a high frequency (17.6%) of haplogroup M1. We statistically and phylogenetically analysed and compared the Gurna population with other Egyptian, Near East and sub-Saharan Africa populations; AMOVA and Minimum Spanning Network analysis showed that the Gurna population was not isolated from neighbouring populations. Our results suggest that the Gurna population has conserved the trace of an ancestral genetic structure from an ancestral East African population, characterized by a high M1 haplogroup frequency. The current structure of the Egyptian population may be the result of further influence of neighbouring populations on this ancestral population.

Similar articles

• Mitochondrial DNA variability in the Czech population, with application to the ethnic history of Slavs.

  Malyarchuk BA, Vanecek T, Perkova MA, Derenko MV, Sip M. Malyarchuk BA, et al. Hum Biol. 2006 Dec;78(6):681-96. doi: 10.1353/hub.2007.0014. Hum Biol. 2006. PMID: 17564247

• Mitochondrial DNA variation in Jordanians and their genetic relationship to other Middle East populations.

  González AM, Karadsheh N, Maca-Meyer N, Flores C, Cabrera VM, Larruga JM. González AM, et al. Ann Hum Biol. 2008 Mar-Apr;35(2):212-31. doi: 10.1080/03014460801946538. Ann Hum Biol. 2008. PMID: 18428014

• Frequency of main western-Euroasian mtDNA haplogroups and paleolithic and neolithic lineages in the genetic structure of population of northeastern Bosnia.

  Ahmić A, Silajdžić E, Lasić L, Kalamujić B, Hadžiavdić V, Kapur-Pojskić L, Bajrović K, Hadžiselimović R, Pojskić N. Ahmić A, et al. Coll Antropol. 2014 Sep;38(3):819-27. Coll Antropol. 2014. PMID: 25420361

• Investigation of mtDNA control region sequences in an Egyptian population sample.

  Elmadawy MA, Nagai A, Gomaa GM, Hegazy HM, Shaaban FE, Bunai Y. Elmadawy MA, et al. Leg Med (Tokyo). 2013 Nov;15(6):338-41. doi: 10.1016/j.legalmed.2013.06.006. Epub 2013 Jul 30. Leg Med (Tokyo). 2013. PMID: 23910099

• The genetic landscape of Mediterranean North African populations through complete mtDNA sequences.

  Font-Porterias N, Solé-Morata N, Serra-Vidal G, Bekada A, Fadhlaoui-Zid K, Zalloua P, Calafell F, Comas D. Font-Porterias N, et al. Ann Hum Biol. 2018 Feb;45(1):98-104. doi: 10.1080/03014460.2017.1413133. Ann Hum Biol. 2018. PMID: 29382280

Cited by

• Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia.

  Sirak KA, Fernandes DM, Lipson M, Mallick S, Mah M, Olalde I, Ringbauer H, Rohland N, Hadden CS, Harney É, Adamski N, Bernardos R, Broomandkhoshbacht N, Callan K, Ferry M, Lawson AM, Michel M, Oppenheimer J, Stewardson K, Zalzala F, Patterson N, Pinhasi R, Thompson JC, Van Gerven D, Reich D. Sirak KA, et al. Nat Commun. 2021 Dec 14;12(1):7283. doi: 10.1038/s41467-021-27356-8. Nat Commun. 2021. PMID: 34907168 Free PMC article.

• Forensic and phylogeographic characterisation of mtDNA lineages from Somalia.

  Mikkelsen M, Fendt L, Röck AW, Zimmermann B, Rockenbauer E, Hansen AJ, Parson W, Morling N. Mikkelsen M, et al. Int J Legal Med. 2012 Jul;126(4):573-9. doi: 10.1007/s00414-012-0694-6. Epub 2012 Apr 14. Int J Legal Med. 2012. PMID: 22527188

• Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears.

  Kivisild T, Reidla M, Metspalu E, Rosa A, Brehm A, Pennarun E, Parik J, Geberhiwot T, Usanga E, Villems R. Kivisild T, et al. Am J Hum Genet. 2004 Nov;75(5):752-70. doi: 10.1086/425161. Epub 2004 Sep 27. Am J Hum Genet. 2004. PMID: 15457403 Free PMC article.

• Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens.

  Loreille O, Ratnayake S, Bazinet AL, Stockwell TB, Sommer DD, Rohland N, Mallick S, Johnson PLF, Skoglund P, Onorato AJ, Bergman NH, Reich D, Irwin JA. Loreille O, et al. Genes (Basel). 2018 Mar 1;9(3):135. doi: 10.3390/genes9030135. Genes (Basel). 2018. PMID: 29494531 Free PMC article.

• On the Etruscan mitochondrial DNA contribution to modern humans.

  Malyarchuk BA, Rogozin IB. Malyarchuk BA, et al. Am J Hum Genet. 2004 Nov;75(5):920-3; author reply 923-7. doi: 10.1086/425220. Am J Hum Genet. 2004. PMID: 15457406 Free PMC article. No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley