pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor - PubMed

Comparative Study

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

H Tei et al. Proc Natl Acad Sci U S A. 1992.

Abstract

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

Similar articles

• JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye.

  Treier M, Bohmann D, Mlodzik M. Treier M, et al. Cell. 1995 Dec 1;83(5):753-60. doi: 10.1016/0092-8674(95)90188-4. Cell. 1995. PMID: 8521492

• An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene.

  Hagman J, Grosschedl R. Hagman J, et al. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8889-93. doi: 10.1073/pnas.89.19.8889. Proc Natl Acad Sci U S A. 1992. PMID: 1409581 Free PMC article.

• Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.

  Krämer H, Cagan RL, Zipursky SL. Krämer H, et al. Nature. 1991 Jul 18;352(6332):207-12. doi: 10.1038/352207a0. Nature. 1991. PMID: 1857416

• Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina.

  Yamamoto D. Yamamoto D. Bioessays. 1994 Apr;16(4):237-44. doi: 10.1002/bies.950160406. Bioessays. 1994. PMID: 8031300 Review.

• Molecular analysis of the ets genes and their products.

  Watson DK, Ascione R, Papas TS. Watson DK, et al. Crit Rev Oncog. 1990;1(4):409-36. Crit Rev Oncog. 1990. PMID: 1964597 Review.

Cited by

• Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.

  Zhang J, Graham TG, Vivekanand P, Cote L, Cetera M, Rebay I. Zhang J, et al. Mol Cell Biol. 2010 Mar;30(5):1158-70. doi: 10.1128/MCB.01225-09. Epub 2010 Jan 4. Mol Cell Biol. 2010. PMID: 20048052 Free PMC article.

• New nucleotide sequence data on the EMBL File Server.

  [No authors listed] [No authors listed] Nucleic Acids Res. 1992 Nov 25;20(22):6119-40. doi: 10.1093/nar/20.22.6119. Nucleic Acids Res. 1992. PMID: 1461752 Free PMC article. No abstract available.

• Dual-tagging gene trap of novel genes in Drosophila melanogaster.

  Lukacsovich T, Asztalos Z, Awano W, Baba K, Kondo S, Niwa S, Yamamoto D. Lukacsovich T, et al. Genetics. 2001 Feb;157(2):727-42. doi: 10.1093/genetics/157.2.727. Genetics. 2001. PMID: 11156992 Free PMC article.

• Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter.

  Giovane A, Sobieszczuk P, Ayadi A, Maira SM, Wasylyk B. Giovane A, et al. Mol Cell Biol. 1997 Oct;17(10):5667-78. doi: 10.1128/MCB.17.10.5667. Mol Cell Biol. 1997. PMID: 9315625 Free PMC article.

• mir-11 limits the proapoptotic function of its host gene, dE2f1.

  Truscott M, Islam AB, López-Bigas N, Frolov MV. Truscott M, et al. Genes Dev. 2011 Sep 1;25(17):1820-34. doi: 10.1101/gad.16947411. Epub 2011 Aug 19. Genes Dev. 2011. PMID: 21856777 Free PMC article.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase
  • GlyGen glycoinformatics resource

• Research Materials

  • National BioResource Project