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Doxorubicin accumulation in individually electrophoresed organelles - PubMed

  • ️Thu Jan 01 2004

. 2004 Aug 4;126(30):9168-9.

doi: 10.1021/ja0492539.

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Doxorubicin accumulation in individually electrophoresed organelles

Adrian B Anderson et al. J Am Chem Soc. 2004.

Abstract

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

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