The SCF ubiquitin ligase: insights into a molecular machine - PubMed

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• PMID: 15340381
• DOI: 10.1038/nrm1471

Review

The SCF ubiquitin ligase: insights into a molecular machine

Timothy Cardozo et al. Nat Rev Mol Cell Biol. 2004 Sep.

Abstract

Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

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