CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes - PubMed

Affiliations

• PMID: 15368288
• DOI: 10.1002/eji.200425125

Free article

CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes

Anna Ericsson et al. Eur J Immunol. 2004 Oct.

Free article

Abstract

The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8(+) intraepithelial lymphocytes (IEL), naïve murine CD8(+) T cells and by a small population of effector/memory CD8(+) T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8(+) T cells following their activation in mesenteric lymph nodes and that effector CD8(+) T cells upon initial entry into the small intestinal epithelium are CCR9(+)CD103(-). CD103 was rapidly induced on wild-type CD8(+) T cells subsequent to their entry into the small intestinal epithelium, however, CCR9(-/-) CD8(+) T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8(+) small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8(+) IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa.

Similar articles

• Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.

  Apostolaki M, Manoloukos M, Roulis M, Wurbel MA, Müller W, Papadakis KA, Kontoyiannis DL, Malissen B, Kollias G. Apostolaki M, et al. Gastroenterology. 2008 Jun;134(7):2025-35. doi: 10.1053/j.gastro.2008.02.085. Epub 2008 Mar 5. Gastroenterology. 2008. PMID: 18439426

• CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin.

  Ericsson A, Arya A, Agace W. Ericsson A, et al. Ann N Y Acad Sci. 2004 Dec;1029:334-6. doi: 10.1196/annals.1309.014. Ann N Y Acad Sci. 2004. PMID: 15681774

• CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa.

  Svensson M, Marsal J, Ericsson A, Carramolino L, Brodén T, Márquez G, Agace WW. Svensson M, et al. J Clin Invest. 2002 Oct;110(8):1113-21. doi: 10.1172/JCI15988. J Clin Invest. 2002. PMID: 12393847 Free PMC article.

• Development and functional specialization of CD103+ dendritic cells.

  del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Förster R. del Rio ML, et al. Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x. Immunol Rev. 2010. PMID: 20193025 Review.

• Alloantigen-induced regulatory CD8+CD103+ T cells.

  Koch SD, Uss E, van Lier RA, ten Berge IJ. Koch SD, et al. Hum Immunol. 2008 Nov;69(11):737-44. doi: 10.1016/j.humimm.2008.08.281. Epub 2008 Sep 24. Hum Immunol. 2008. PMID: 18822329 Review.

Cited by

• Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation.

  Qiu Z, Khairallah C, Chu TH, Imperato JN, Lei X, Romanov G, Atakilit A, Puddington L, Sheridan BS. Qiu Z, et al. J Exp Med. 2023 May 1;220(5):e20210923. doi: 10.1084/jem.20210923. Epub 2023 Feb 21. J Exp Med. 2023. PMID: 36809399 Free PMC article.

• Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing.

  Johansson-Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Förster R, Agace WW. Johansson-Lindbom B, et al. J Exp Med. 2005 Oct 17;202(8):1063-73. doi: 10.1084/jem.20051100. Epub 2005 Oct 10. J Exp Med. 2005. PMID: 16216890 Free PMC article.

• The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ⁺CD8αα⁺ intestinal intraepithelial lymphocytes.

  Zhang H, Hu Y, Liu D, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X. Zhang H, et al. Cell Death Differ. 2022 Jul;29(7):1349-1363. doi: 10.1038/s41418-021-00921-w. Epub 2022 Jan 9. Cell Death Differ. 2022. PMID: 34999729 Free PMC article.

• Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

  Shang L, Thirunarayanan N, Viejo-Borbolla A, Martin AP, Bogunovic M, Marchesi F, Unkeless JC, Ho Y, Furtado GC, Alcami A, Merad M, Mayer L, Lira SA. Shang L, et al. Gastroenterology. 2009 Sep;137(3):1006-18, 1018.e1-3. doi: 10.1053/j.gastro.2009.05.055. Epub 2009 Jun 6. Gastroenterology. 2009. PMID: 19501588 Free PMC article.

• Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice.

  Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Cassani B, et al. Gastroenterology. 2011 Dec;141(6):2109-18. doi: 10.1053/j.gastro.2011.09.015. Epub 2011 Sep 16. Gastroenterology. 2011. PMID: 21925467 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program