Context-dependency of the relation between left ventricular mass and AGT gene variants - PubMed

Affiliations

• PMID: 15483663
• DOI: 10.1038/sj.jhh.1001793

Comparative Study

Context-dependency of the relation between left ventricular mass and AGT gene variants

T Kuznetsova et al. J Hum Hypertens. 2005 Feb.

Abstract

In the European Project on Genes in Hypertension (EPOGH), we investigated in three populations to what extent in a family-based study, left ventricular mass (LVM) was associated with the C-532T and G-6A polymorphisms in the angiotensinogen (AGT) gene. We randomly recruited 221 nuclear families (384 parents and 440 offspring) in Cracow (Poland), Novosibirsk (Russia), and Mirano (Italy). Echocardiographic LVM was indexed to body surface area, adjusted for covariables, and subjected to multivariate analyses, using generalized estimating equations and quantitative transmission disequilibrium tests in a population-based and family-based approach, respectively. We found significant differences between the two Slavic centres and Mirano in left ventricular mass index (LVMI) (94.9 vs 80.4 g/m2), sodium excretion (229 vs 186 mmol/day), and the prevalence of the AGT -6A (55.7 vs 40.6%) and -532T (16.8 vs 9.4%) alleles. In population-based as well as in family-based analyses, we observed positive associations of LVMI and mean wall thickness (MWT) with the -532T allele in Slavic, but not in Italian male offspring. Furthermore, in Slavic male offspring, LVMI and MWT were significantly higher in carriers of the -532T/-6A haplotype than in those with the -532C/-6G or -532C/-6A allele combinations. In women, LVMI was neither associated with single AGT gene variants nor with the haplotypes (0.19 < P <0.98). In Slavic offspring carrying the AGT -532C/-6G or -532C/-6A haplotypes, LVMI significantly increased with higher sodium excretion (+3.5 g/m2/100 mmol; P=0.003), whereas such association was not present in -532T/-6A haplotype carriers (P-value for interaction 0.04). We found a positive association between LVMI and the AGT -532T allele due to increased MWT. This relation was observed in Slavic male offspring. It was therefore dependent on gender, age and ecogenetic context, and in addition it appeared to be modulated by the trophic effects of salt intake on LVM.

Similar articles

• Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake.

  Kuznetsova T, Staessen JA, Stolarz K, Ryabikov A, Tikhonoff V, Olszanecka A, Bianchi G, Brand E, Casiglia E, Dominiczak A, Fagard R, Malyutina S, Nikitin Y, Kawecka-Jaszcz K; European Project On Genes in Hypertension (EPOGH) Investigators. Kuznetsova T, et al. J Hypertens. 2004 Feb;22(2):287-95. doi: 10.1097/00004872-200402000-00012. J Hypertens. 2004. PMID: 15076186

• Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion.

  Kuznetsova T, Staessen JA, Thijs L, Kunath C, Olszanecka A, Ryabikov A, Tikhonoff V, Stolarz K, Bianchi G, Casiglia E, Fagard R, Brand-Herrmann SM, Kawecka-Jaszcz K, Malyutina S, Nikitin Y, Brand E; European Project On Genes in Hypertension (EPOGH) Investigators. Kuznetsova T, et al. Circulation. 2004 Oct 26;110(17):2644-50. doi: 10.1161/01.CIR.0000145541.63406.BA. Epub 2004 Oct 18. Circulation. 2004. PMID: 15492316

• Angiotensinogen promoter haplotypes are associated with blood pressure in untreated hypertensives.

  Brand-Herrmann SM, Köpke K, Reichenberger F, Schmidt-Petersen K, Reineke T, Paul M, Zidek W, Brand E. Brand-Herrmann SM, et al. J Hypertens. 2004 Jul;22(7):1289-97. doi: 10.1097/01.hjh.0000125429.28861.58. J Hypertens. 2004. PMID: 15201544

• [Role of the angiotensinogen gene for essential hypertension].

  Brand E, Ringel J, Sharma AM. Brand E, et al. Herz. 2000 Feb;25(1):15-25. doi: 10.1007/BF03044120. Herz. 2000. PMID: 10713906 Review. German.

• A haplotype of the angiotensinogen gene is associated with hypertension in african americans.

  Kumar A, Li Y, Patil S, Jain S. Kumar A, et al. Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):495-502. doi: 10.1111/j.1440-1681.2005.04217.x. Clin Exp Pharmacol Physiol. 2005. PMID: 15854165 Review.

Cited by

• Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy.

  Lieb W, Graf J, Götz A, König IR, Mayer B, Fischer M, Stritzke J, Hengstenberg C, Holmer SR, Döring A, Löwel H, Schunkert H, Erdmann J. Lieb W, et al. J Mol Med (Berl). 2006 Jan;84(1):88-96. doi: 10.1007/s00109-005-0718-5. Epub 2005 Nov 11. J Mol Med (Berl). 2006. PMID: 16283142

• Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension.

  Palatini P, Casiglia E, Gąsowski J, Głuszek J, Jankowski P, Narkiewicz K, Saladini F, Stolarz-Skrzypek K, Tikhonoff V, Van Bortel L, Wojciechowska W, Kawecka-Jaszcz K. Palatini P, et al. Vasc Health Risk Manag. 2011;7:725-39. doi: 10.2147/VHRM.S25270. Epub 2011 Dec 7. Vasc Health Risk Manag. 2011. PMID: 22174583 Free PMC article. Review.

• Heritability of left ventricular structure and function in Caucasian families.

  Jin Y, Kuznetsova T, Bochud M, Richart T, Thijs L, Cusi D, Fagard R, Staessen JA. Jin Y, et al. Eur J Echocardiogr. 2011 Apr;12(4):326-32. doi: 10.1093/ejechocard/jer019. Epub 2011 Mar 11. Eur J Echocardiogr. 2011. PMID: 21398654 Free PMC article.

• Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study.

  Lynch AI, Tang W, Shi G, Devereux RB, Eckfeldt JH, Arnett DK. Lynch AI, et al. J Hum Hypertens. 2012 Feb;26(2):133-40. doi: 10.1038/jhh.2010.131. Epub 2011 Jan 20. J Hum Hypertens. 2012. PMID: 21248783 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Miscellaneous

  • NCI CPTAC Assay Portal