Gene map of the extended human MHC - PubMed

Affiliations

• PMID: 15573121
• DOI: 10.1038/nrg1489

Review

Gene map of the extended human MHC

Roger Horton et al. Nat Rev Genet. 2004 Dec.

Abstract

The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

Similar articles

• Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium.

  [No authors listed] [No authors listed] Nature. 1999 Oct 28;401(6756):921-3. doi: 10.1038/44853. Nature. 1999. PMID: 10553908

• Genomic structure and function in the MHC.

  Trowsdale J. Trowsdale J. Trends Genet. 1993 Apr;9(4):117-22. doi: 10.1016/0168-9525(93)90205-v. Trends Genet. 1993. PMID: 8516845 Review.

• Comparative genomics of the human, macaque and mouse major histocompatibility complex.

  Shiina T, Blancher A, Inoko H, Kulski JK. Shiina T, et al. Immunology. 2017 Feb;150(2):127-138. doi: 10.1111/imm.12624. Epub 2016 Jul 10. Immunology. 2017. PMID: 27395034 Free PMC article. Review.

• Genomic structure of a 200kb region between HLA-C and TNF: implications for transplantation, autoimmune disease and evolution.

  Townend DC, Gaudieri S, Leelayuwat C, Tay GK, Degli-Esposti MP, Dawkins RL. Townend DC, et al. DNA Seq. 1996;7(1):55-9. DNA Seq. 1996. PMID: 9063641 No abstract available.

• Polymorphic Alu insertions within the Major Histocompatibility Complex class I genomic region: a brief review.

  Kulski JK, Dunn DS. Kulski JK, et al. Cytogenet Genome Res. 2005;110(1-4):193-202. doi: 10.1159/000084952. Cytogenet Genome Res. 2005. PMID: 16093672 Review.

Cited by

• Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

  Lenz TL, Spirin V, Jordan DM, Sunyaev SR. Lenz TL, et al. Mol Biol Evol. 2016 Oct;33(10):2555-64. doi: 10.1093/molbev/msw127. Epub 2016 Jun 28. Mol Biol Evol. 2016. PMID: 27436009 Free PMC article.

• Splenic protection network revealed by transcriptome analysis in inactivated vaccine-immunized flounder (Paralichthys olivaceus) against Edwardsiella tarda infection.

  Wu X, Xing J, Tang X, Sheng X, Chi H, Zhan W. Wu X, et al. Front Immunol. 2022 Nov 9;13:1058599. doi: 10.3389/fimmu.2022.1058599. eCollection 2022. Front Immunol. 2022. PMID: 36439120 Free PMC article.

• Unveiling the Immunogenicity of Ovarian Tumors as the Crucial Catalyst for Therapeutic Success.

  Rodriguez GM, Yakubovich E, Vanderhyden BC. Rodriguez GM, et al. Cancers (Basel). 2023 Dec 2;15(23):5694. doi: 10.3390/cancers15235694. Cancers (Basel). 2023. PMID: 38067396 Free PMC article. Review.

• A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure.

  Tiezzi F, Parker-Gaddis KL, Cole JB, Clay JS, Maltecca C. Tiezzi F, et al. PLoS One. 2015 Feb 6;10(2):e0114919. doi: 10.1371/journal.pone.0114919. eCollection 2015. PLoS One. 2015. PMID: 25658712 Free PMC article.

• Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci.

  Ahn R, Ding YC, Murray J, Fasano A, Green PH, Neuhausen SL, Garner C. Ahn R, et al. PLoS One. 2012;7(5):e36926. doi: 10.1371/journal.pone.0036926. Epub 2012 May 17. PLoS One. 2012. PMID: 22615847 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program