Cytokines and psychopathology: lessons from interferon-alpha - PubMed

Review

Cytokines and psychopathology: lessons from interferon-alpha

Lucile Capuron et al. Biol Psychiatry. 2004.

Abstract

Interferon-alpha is a potent inducer of the cytokine network and is notorious for causing behavioral alterations. Studies on interferon-alpha-treated patients reveal at least two distinct syndromes: 1) a mood/cognitive syndrome that appears late during interferon-alpha therapy is responsive to antidepressants and is associated with activation of neuroendocrine pathways and altered serotonin metabolism; and 2) a neurovegetative syndrome characterized by psychomotor slowing, and fatigue that appears early during interferon-alpha treatment is antidepressant nonresponsive and may be mediated by alterations in basal ganglia dopamine metabolism. Findings from interferon-alpha may provide important clues regarding the pathophysiology and treatment of cytokine-induced behavioral changes in medically ill patients, while also potentially modeling the development of neuropsychiatric symptoms in patients without medical disorders.

Similar articles

• [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression].

  Capuron L, Dantzer R, Miller AH. Capuron L, et al. J Soc Biol. 2003;197(2):151-6. J Soc Biol. 2003. PMID: 12910630 Review. French.

• Cytokines and brain function: relevance to interferon-alpha-induced mood and cognitive changes.

  Licinio J, Kling MA, Hauser P. Licinio J, et al. Semin Oncol. 1998 Feb;25(1 Suppl 1):30-8. Semin Oncol. 1998. PMID: 9482538 Review.

• Mood and cognitive side effects of interferon-alpha therapy.

  Valentine AD, Meyers CA, Kling MA, Richelson E, Hauser P. Valentine AD, et al. Semin Oncol. 1998 Feb;25(1 Suppl 1):39-47. Semin Oncol. 1998. PMID: 9482539 Review.

• [Neuropsychiatric symptoms related to interferon alpha].

  Małyszczak K, Inglot M, Pawłowski T, Czarnecki M, Rymer W, Kiejna A. Małyszczak K, et al. Psychiatr Pol. 2006 Jul-Aug;40(4):787-97. Psychiatr Pol. 2006. PMID: 17068950 Review. Polish.

• Neuropsychiatric adverse effects of interferon-alpha: recognition and management.

  Raison CL, Demetrashvili M, Capuron L, Miller AH. Raison CL, et al. CNS Drugs. 2005;19(2):105-23. doi: 10.2165/00023210-200519020-00002. CNS Drugs. 2005. PMID: 15697325 Free PMC article. Review.

Cited by

• Cytokine variations and mood disorders: influence of social stressors and social support.

  Audet MC, McQuaid RJ, Merali Z, Anisman H. Audet MC, et al. Front Neurosci. 2014 Dec 16;8:416. doi: 10.3389/fnins.2014.00416. eCollection 2014. Front Neurosci. 2014. PMID: 25565946 Free PMC article. Review.

• Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge.

  Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC. Salazar A, et al. Horm Behav. 2012 Aug;62(3):202-9. doi: 10.1016/j.yhbeh.2012.03.010. Epub 2012 Mar 31. Horm Behav. 2012. PMID: 22504306 Free PMC article. Review.

• Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.

  Felger JC, Treadway MT. Felger JC, et al. Neuropsychopharmacology. 2017 Jan;42(1):216-241. doi: 10.1038/npp.2016.143. Epub 2016 Aug 2. Neuropsychopharmacology. 2017. PMID: 27480574 Free PMC article. Review.

• Associations between vitamin D levels and depressive symptoms in healthy young adult women.

  Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF. Kerr DC, et al. Psychiatry Res. 2015 May 30;227(1):46-51. doi: 10.1016/j.psychres.2015.02.016. Epub 2015 Mar 5. Psychiatry Res. 2015. PMID: 25791903 Free PMC article.

• Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities.

  Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. Savitz J, et al. Brain Behav Immun. 2013 Jul;31:161-71. doi: 10.1016/j.bbi.2012.10.007. Epub 2012 Oct 12. Brain Behav Immun. 2013. PMID: 23064081 Free PMC article.

Publication types

MeSH terms

Substances