pubmed.ncbi.nlm.nih.gov

Manganese toxicity upon overexposure - PubMed

Review

Manganese toxicity upon overexposure

Janelle Crossgrove et al. NMR Biomed. 2004 Dec.

Abstract

Manganese (Mn) is a required element and a metabolic byproduct of the contrast agent mangafodipir trisodium (MnDPDP). The Mn released from MnDPDP is initially sequestered by the liver for first-pass elimination, which allows an enhanced contrast for diagnostic imaging. The administration of intravenous Mn impacts its homeostatic balance in the human body and can lead to toxicity. Human Mn deficiency has been reported in patients on parenteral nutrition and in micronutrient studies. Mn toxicity has been reported through occupational (e.g. welder) and dietary overexposure and is evidenced primarily in the central nervous system, although lung, cardiac, liver, reproductive and fetal toxicity have been noted. Mn neurotoxicity results from an accumulation of the metal in brain tissue and results in a progressive disorder of the extrapyramidal system which is similar to Parkinson's disease. In order for Mn to distribute from blood into brain tissue, it must cross either the blood-brain barrier (BBB) or the blood-cerebrospinal fluid barrier (BCB). Brain import, with no evidence of export, would lead to brain Mn accumulation and neurotoxicity. The mechanism for the neurodegenerative damage specific to select brain regions is not clearly understood. Disturbances in iron homeostasis and the valence state of Mn have been implicated as key factors in contributing to Mn toxicity. Chelation therapy with EDTA and supplementation with levodopa are the current treatment options, which are mildly and transiently efficacious. In conclusion, repeated administration of Mn, or compounds that readily release Mn, may increase the risk of Mn-induced toxicity.

PubMed Disclaimer

Cited by

Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb.
Zhang LL, Lu L, Pan YJ, Ding CG, Xu DY, Huang CF, Pan XF, Zheng W. Zhang LL, et al. Environ Res. 2015 Jul;140:10-7. doi: 10.1016/j.envres.2015.03.008. Epub 2015 Mar 31. Environ Res. 2015. PMID: 25836720 Free PMC article.
Manganese Toxicity Upon Overexposure: a Decade in Review.
O'Neal SL, Zheng W. O'Neal SL, et al. Curr Environ Health Rep. 2015 Sep;2(3):315-28. doi: 10.1007/s40572-015-0056-x. Curr Environ Health Rep. 2015. PMID: 26231508 Free PMC article. Review.
Biological Manganese Removal by Novel Halotolerant Bacteria Isolated from River Water.
Nguyen VK, Ha MG, Kang HY, Nguyen DD. Nguyen VK, et al. Biomolecules. 2020 Jun 22;10(6):941. doi: 10.3390/biom10060941. Biomolecules. 2020. PMID: 32580482 Free PMC article.
Morphographic Changes in the Electrocardiogram of Colossoma macropomum Caused by Exposure to Manganese.
Nascimento LMD, Dos Santos MF, Paz CAD, de Araújo DB, Ferreira RDC, Deiga YDS, de Souza LV, Câmara TM, Dos Santos RG, Barbosa AS, Hamoy MKO, do Amaral ALG, Eiró-Quirino L, Cabral TDS, da Silva MAPS, Muto NA, Hamoy M. Nascimento LMD, et al. Int J Mol Sci. 2024 Aug 16;25(16):8910. doi: 10.3390/ijms25168910. Int J Mol Sci. 2024. PMID: 39201596 Free PMC article.
Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation.
Robison G, Sullivan B, Cannon JR, Pushkar Y. Robison G, et al. Metallomics. 2015 May;7(5):748-55. doi: 10.1039/c5mt00023h. Epub 2015 Feb 19. Metallomics. 2015. PMID: 25695229 Free PMC article.

References

1. Keen CL, Ensunsa JL, Clegg MS. Manganese metabolism in animals and humans including the toxicity of manganese. In: Sigel A, Sigel H, editors. Manganese and its Role in Biological Processes. Marcel Dekker; New York: 2000. pp. 89–121. - PubMed
1. Carl GF, Gallagher BB. Manganese and epilepsy. In: Klimis-Tavantzis DJ, editor. Manganese in Health and Disease. CRC Press; Boca Raton, FL: 1994. pp. 133–143.
1. Wedler FC, Denman RB. Glutamine synthetase: the major Mn(II) enzyme in mammalian brain. Curr. Top. Cell Regul. 1984;24:153–169. - PubMed
1. Dickerson RN. Manganese intoxication and parenteral nutrition. Nutrition. 2001;17(7–8):689–693. - PubMed
1. Friedman BJ, Freeland-Graves JH, Bales CW, Behmardi F, Shorey-Kutschke RL, Willis RA, Crosby JB, Trickett PC, Houston SD. Manganese balance and clinical observations in young men fed a manganese-deficient diet. J. Nutr. 1987;117(1):133–143. - PubMed

Manganese toxicity upon overexposure - PubMed