An unusual form of autoimmune hepatitis in young Somalian men - PubMed
Comparative Study
An unusual form of autoimmune hepatitis in young Somalian men
R D'Souza et al. Liver Int. 2005 Apr.
Abstract
Background: Significant diversity in disease severity has been identified for autoimmune disorders among different ethnic groups. Current knowledge of both the natural history and management of autoimmune hepatitis (AIH) has been derived from European or Japanese patients, and there is limited information about the disease in patients from other ethnic groups.
Aims: To assess the clinical, histological and immunological features of AIH in patients from Somalia and to determine their response to therapy.
Methods: Retrospective review of a cohort of young Somalian men with atypical AIH compared with a control group of European patients.
Results: The six Somalian men were younger at presentation (median age 37 (range 24-59) years) than the seven female and three male European controls (55 (34-54) years, P = 0.06). The Somalians had slightly more severe disease at presentation-median modified Ishak stage of 2.5 compared with 2 in Europeans (P = 0.61) and four (66%) had features of cholestasis compared with only one (10%) European patient (P = 0.04). Therapy with prednisolone and azathioprine was completely effective for eight of 10 Europeans but only one of seven Somalians (P = 0.04). Analysis of human leucocyte antigen types revealed differences between the Somalian and European patients, although these differences did not reach statistical significance.
Conclusions: Somalian men with AIH present with cholestatic features and respond poorly to standard immunosuppressive regimes.
Copyright Blackwell Munksgaard 2005
Similar articles
-
Fallatah HI, Akbar HO, Qari YA. Fallatah HI, et al. Saudi J Gastroenterol. 2010 Apr-Jun;16(2):95-9. doi: 10.4103/1319-3767.61235. Saudi J Gastroenterol. 2010. PMID: 20339178 Free PMC article.
-
Characteristics of autoimmune hepatitis in patients who are not of European Caucasoid ethnic origin.
Zolfino T, Heneghan MA, Norris S, Harrison PM, Portmann BC, McFarlane IG. Zolfino T, et al. Gut. 2002 May;50(5):713-7. doi: 10.1136/gut.50.5.713. Gut. 2002. PMID: 11950822 Free PMC article.
-
Gordon V, Adhikary R, Appleby V, Das D, Day J, Delahooke T, Dixon S, Elphick D, Hardie C, Hoeroldt B, Hooper P, Hutchinson J, Jones R, Khan F, Aithal GP, McGonigle J, Nelson A, Nkhoma A, Pelitari S, Prince M, Prosser A, Sathanarayana V, Savva S, Shah N, Saksena S, Thayalasekaran S, Vani D, Yeoman A, Gleeson D; UK Multi-Centre AIH Audit Group. Gordon V, et al. Liver Int. 2018 Sep;38(9):1686-1695. doi: 10.1111/liv.13724. Epub 2018 Apr 12. Liver Int. 2018. PMID: 29455458
-
[Autoimmune liver diseases and their overlap syndromes].
Strassburg CP. Strassburg CP. Praxis (Bern 1994). 2006 Sep 6;95(36):1363-81. doi: 10.1024/1661-8157.95.36.1363. Praxis (Bern 1994). 2006. PMID: 16989180 Review. German.
-
Autoimmune hepatitis: East meets west.
Yang F, Wang Q, Bian Z, Ren LL, Jia J, Ma X. Yang F, et al. J Gastroenterol Hepatol. 2015 Aug;30(8):1230-6. doi: 10.1111/jgh.12952. J Gastroenterol Hepatol. 2015. PMID: 25765710 Review.
Cited by
-
Autoimmune hepatitis--approach to diagnosis.
Czaja AJ. Czaja AJ. MedGenMed. 2006 May 23;8(2):55. MedGenMed. 2006. PMID: 16926794 Free PMC article. Review.
-
Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM. Lee B, et al. Autoimmunity. 2018 Aug;51(5):258-264. doi: 10.1080/08916934.2018.1482884. Epub 2018 Jun 11. Autoimmunity. 2018. PMID: 29890851 Free PMC article.
-
Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment.
Czaja AJ, Bayraktar Y. Czaja AJ, et al. World J Gastroenterol. 2009 May 21;15(19):2314-28. doi: 10.3748/wjg.15.2314. World J Gastroenterol. 2009. PMID: 19452572 Free PMC article. Review.
-
Khat (Catha Edulis) as a possible cause of autoimmune hepatitis.
Riyaz S, Imran M, Gleeson D, Karajeh MA. Riyaz S, et al. World J Hepatol. 2014 Mar 27;6(3):150-4. doi: 10.4254/wjh.v6.i3.150. World J Hepatol. 2014. PMID: 24672645 Free PMC article.
-
Autoimmune hepatitis: a review of current diagnosis and treatment.
Makol A, Watt KD, Chowdhary VR. Makol A, et al. Hepat Res Treat. 2011;2011:390916. doi: 10.1155/2011/390916. Epub 2011 May 15. Hepat Res Treat. 2011. PMID: 21760995 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical