Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages - PubMed

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• PMID: 15834471
• DOI: 10.1039/b500638d

Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

Julien Leclaire et al. Chem Commun (Camb). 2005.

Abstract

Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.

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