Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization - PubMed
Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization
Iris Halbwedl et al. Gynecol Oncol. 2005 May.
Abstract
Objective: Endometrial stromal sarcomas (ESS) are very rare neoplasms constituting less than 0.5% of all malignant uterine tumors. The aim of the present study was to characterize the karyotypic abnormalities in these malignant mesenchymal tumors and to find specific chromosomal aberrations with eventual correlation with histologic grades.
Methods: Twelve cases of endometrial stromal sarcomas consisting of nine low-grade ESS and three undifferentiated endometrial sarcomas (UES) were investigated by comparative genomic hybridization (CGH).
Results: Ten of the twelve cases (83.3%) displayed chromosomal gains or losses. Deletions occurred more frequently than gains (63.4% versus 36.6%). In low-grade ESS, gains on 1, 6q, 9q, 16p, 19, 20q, 22q and losses on 2, 4q, 6, 7, 11q, 13q, 15q, 16q, 20p, X were detected. CGH with UES exhibited gains on 2q, 4q, 6q, 7p, 9q, 20q and losses on 3q, 10p, 14q. One low-grade ESS and one UES did not reveal any chromosomal aberration.
Conclusions: Chromosomal aberrations in endometrial sarcomas are heterogeneous and do not clearly correlate with the histologic grades. There is no increased accumulation of aberrations from low-grade ESS to UES. Despite the karyotypic variations, chromosomal deletion on 7p was the most common finding (55.6%) in low-grade ESS and may play a role in tumor development and progression.
Similar articles
-
Genomic aberrations in carcinomas of the uterine corpus.
Micci F, Teixeira MR, Haugom L, Kristensen G, Abeler VM, Heim S. Micci F, et al. Genes Chromosomes Cancer. 2004 Jul;40(3):229-46. doi: 10.1002/gcc.20038. Genes Chromosomes Cancer. 2004. PMID: 15139002
-
Flicker K, Smolle E, Haybaeck J, Moinfar F. Flicker K, et al. Exp Mol Pathol. 2015 Jun;98(3):367-74. doi: 10.1016/j.yexmp.2015.03.009. Epub 2015 Mar 7. Exp Mol Pathol. 2015. PMID: 25758203
-
Interphase cytogenetic study of endometrial stromal sarcoma by chromosome in situ hybridization.
Cheung AN, Tin VP, Ngan HY, Chung LP, Khoo US. Cheung AN, et al. Mod Pathol. 1996 Sep;9(9):910-8. Mod Pathol. 1996. PMID: 8878023
-
Pathogenetic mechanisms in endometrial stromal sarcoma.
Micci F, Heim S. Micci F, et al. Cytogenet Genome Res. 2007;118(2-4):190-5. doi: 10.1159/000108300. Cytogenet Genome Res. 2007. PMID: 18000370 Review. No abstract available.
-
Endometrial stromal sarcoma of uterus.
Xue WC, Cheung AN. Xue WC, et al. Best Pract Res Clin Obstet Gynaecol. 2011 Dec;25(6):719-32. doi: 10.1016/j.bpobgyn.2011.07.004. Epub 2011 Aug 6. Best Pract Res Clin Obstet Gynaecol. 2011. PMID: 21820965 Review.
Cited by
-
Endometrial stromal sarcoma of uterus with metastasis to the lung and brain.
Akhavan A, Shishebor F, Moghimi M, Binesh F. Akhavan A, et al. BMJ Case Rep. 2012 Sep 17;2012:bcr2012006954. doi: 10.1136/bcr-2012-006954. BMJ Case Rep. 2012. PMID: 22987911 Free PMC article.
-
Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas.
Przybyl J, Kowalewska M, Quattrone A, Dewaele B, Vanspauwen V, Varma S, Vennam S, Newman AM, Swierniak M, Bakuła-Zalewska E, Siedlecki JA, Bidzinski M, Cools J, van de Rijn M, Debiec-Rychter M. Przybyl J, et al. JCI Insight. 2017 Jun 2;2(11):e94033. doi: 10.1172/jci.insight.94033. eCollection 2017 Jun 2. JCI Insight. 2017. PMID: 28570276 Free PMC article.
-
Endometrial stromal sarcoma: A review of the literature.
Puliyath G, Nair MK. Puliyath G, et al. Indian J Med Paediatr Oncol. 2012 Jan;33(1):1-6. doi: 10.4103/0971-5851.96960. Indian J Med Paediatr Oncol. 2012. PMID: 22754201 Free PMC article.
-
Molecular profiling of endometrial malignancies.
Samarnthai N, Hall K, Yeh IT. Samarnthai N, et al. Obstet Gynecol Int. 2010;2010:162363. doi: 10.1155/2010/162363. Epub 2010 Mar 28. Obstet Gynecol Int. 2010. PMID: 20368795 Free PMC article.
-
Sardinha R, Hernández T, Fraile S, Tresserra F, Vidal A, Gómez MC, Astudillo A, Hernández N, Saenz de Santamaría J, Ordi J, Gonçalves L, Ramos R, Balañá C, de Álava E. Sardinha R, et al. Clin Sarcoma Res. 2013 Mar 7;3(1):3. doi: 10.1186/2045-3329-3-3. Clin Sarcoma Res. 2013. PMID: 23497641 Free PMC article.