Biological effects of TrkA and TrkB receptor signaling in neuroblastoma - PubMed

Review

Biological effects of TrkA and TrkB receptor signaling in neuroblastoma

Alexander Schramm et al. Cancer Lett. 2005.

Abstract

The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells. Expression of Trk receptors also plays an important role in the biology and clinical behavior of neuroblastomas. High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma.

Similar articles

• Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma.

  Eggert A, Ikegaki N, Liu XG, Brodeur GM. Eggert A, et al. Klin Padiatr. 2000 Jul-Aug;212(4):200-5. doi: 10.1055/s-2000-9677. Klin Padiatr. 2000. PMID: 10994551

• Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.

  Schulte JH, Schramm A, Klein-Hitpass L, Klenk M, Wessels H, Hauffa BP, Eils J, Eils R, Brodeur GM, Schweigerer L, Havers W, Eggert A. Schulte JH, et al. Oncogene. 2005 Jan 6;24(1):165-77. doi: 10.1038/sj.onc.1208000. Oncogene. 2005. PMID: 15637590

• Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells.

  Schulte JH, Kuhfittig-Kulle S, Klein-Hitpass L, Schramm A, Biard DS, Pfeiffer P, Eggert A. Schulte JH, et al. DNA Repair (Amst). 2008 Oct 1;7(10):1757-64. doi: 10.1016/j.dnarep.2008.07.004. Epub 2008 Aug 20. DNA Repair (Amst). 2008. PMID: 18678285

• Trk receptor expression and inhibition in neuroblastomas.

  Brodeur GM, Minturn JE, Ho R, Simpson AM, Iyer R, Varela CR, Light JE, Kolla V, Evans AE. Brodeur GM, et al. Clin Cancer Res. 2009 May 15;15(10):3244-50. doi: 10.1158/1078-0432.CCR-08-1815. Epub 2009 May 5. Clin Cancer Res. 2009. PMID: 19417027 Free PMC article. Review.

• Trk kinase inhibitors as new treatments for cancer and pain.

  Wang T, Yu D, Lamb ML. Wang T, et al. Expert Opin Ther Pat. 2009 Mar;19(3):305-19. doi: 10.1517/13543770902721261. Expert Opin Ther Pat. 2009. PMID: 19441906 Review.

Cited by

• TrkB/BDNF signalling patterns the sympathetic nervous system.

  Kasemeier-Kulesa JC, Morrison JA, Lefcort F, Kulesa PM. Kasemeier-Kulesa JC, et al. Nat Commun. 2015 Sep 25;6:8281. doi: 10.1038/ncomms9281. Nat Commun. 2015. PMID: 26404565 Free PMC article.

• Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer.

  Yu X, Liu L, Cai B, He Y, Wan X. Yu X, et al. Cancer Sci. 2008 Mar;99(3):543-52. doi: 10.1111/j.1349-7006.2007.00722.x. Epub 2008 Jan 14. Cancer Sci. 2008. PMID: 18201274 Free PMC article.

• Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.

  Akil H, Perraud A, Mélin C, Jauberteau MO, Mathonnet M. Akil H, et al. PLoS One. 2011;6(9):e25097. doi: 10.1371/journal.pone.0025097. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966426 Free PMC article.

• Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.

  Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R. Dewitt J, et al. Oncogene. 2014 Feb 20;33(8):977-85. doi: 10.1038/onc.2013.39. Epub 2013 Mar 4. Oncogene. 2014. PMID: 23455321 Free PMC article.

• AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia.

  Gonçalves-Alves E, Garcia M, Rodríguez-Hernández CJ, Gómez-González S, Ecker RC, Suñol M, Muñoz-Aznar O, Carcaboso AM, Mora J, Lavarino C, Mateo-Lozano S. Gonçalves-Alves E, et al. Int J Mol Sci. 2022 Apr 13;23(8):4323. doi: 10.3390/ijms23084323. Int J Mol Sci. 2022. PMID: 35457141 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information