Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination - PubMed

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• PMID: 15951824
• DOI: 10.1038/nm1257

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

Vladimir P Badovinac et al. Nat Med. 2005 Jul.

Abstract

Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4-6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-gamma receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-gamma on the responding T cells, control the rate of development of memory CD8+ T cells.

Comment in

• Vaccine development: baring the 'dirty little secret'.

  Woodland DL, Blackman MA. Woodland DL, et al. Nat Med. 2005 Jul;11(7):715-6. doi: 10.1038/nm0705-715. Nat Med. 2005. PMID: 16015358 No abstract available.

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