Dermatofibrosarcoma protuberans: treatment and prognosis - PubMed
Affiliations
- PMID: 1607035
Review
Dermatofibrosarcoma protuberans: treatment and prognosis
E J Rutgers et al. Eur J Surg Oncol. 1992 Jun.
Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare tumor of the skin with a strong tendency to recur locally. Nineteen cases of DFSP are presented. In eight of them a total of 20 local recurrences occurred, in five after irradical and in three after 'narrow' excisions. After wide excision (greater than 2 cm) for primary or wide re-excision for recurrent tumor, all patients remained free of tumor with a mean follow-up of 13.2 years (range 2-28 years). An extensive literature review revealed 913 cases of DFSP. The overall recurrence rate is about 50%; after adequate wide excision, 13%. Recurrent tumor is safely treated by wide re-excision and the recurrence rate is then 12%. Regional and distant recurrences are infrequent. Eleven cases (1%) were reported to have regional lymph node metastases and 37 (4%, 17 of whom were histologically confirmed) distant metastases, principally in the lung. The prognosis after appearance of regional or distant recurrence is bad. The role of radiotherapy in the management of this tumor is unclear. Primary or recurrent DFSP is best treated by surgical excision with a minimal margin of 2- preferably 3-cm of surrounding skin including the underlying fascia. Elective lymph node dissection is not advised.
Similar articles
-
Snow SN, Gordon EM, Larson PO, Bagheri MM, Bentz ML, Sable DB. Snow SN, et al. Cancer. 2004 Jul 1;101(1):28-38. doi: 10.1002/cncr.20316. Cancer. 2004. PMID: 15221986
-
[Realization of clinical diagnoses and treatment for dermatofibrosarcoma protuberans].
Cai H, Shi YQ, Wang YN, Zhu HY, Mo SJ. Cai H, et al. Zhonghua Wai Ke Za Zhi. 2004 Jun 7;42(11):678-82. Zhonghua Wai Ke Za Zhi. 2004. PMID: 15329259 Chinese.
-
DuBay D, Cimmino V, Lowe L, Johnson TM, Sondak VK. DuBay D, et al. Cancer. 2004 Mar 1;100(5):1008-16. doi: 10.1002/cncr.20051. Cancer. 2004. PMID: 14983497
-
Smola MG, Soyer HP, Scharnagl E. Smola MG, et al. Eur J Surg Oncol. 1991 Oct;17(5):447-53. Eur J Surg Oncol. 1991. PMID: 1936291 Review.
-
Fiore M, Miceli R, Mussi C, Lo Vullo S, Mariani L, Lozza L, Collini P, Olmi P, Casali PG, Gronchi A. Fiore M, et al. J Clin Oncol. 2005 Oct 20;23(30):7669-75. doi: 10.1200/JCO.2005.02.5122. J Clin Oncol. 2005. PMID: 16234529 Review.
Cited by
-
Wide Local Excision for Dermatofibrosarcoma Protuberans: A Single-Center Series of 90 Patients.
Kim BJ, Kim H, Jin US, Minn KW, Chang H. Kim BJ, et al. Biomed Res Int. 2015;2015:642549. doi: 10.1155/2015/642549. Epub 2015 Nov 25. Biomed Res Int. 2015. PMID: 26688814 Free PMC article.
-
Zheng Z, Piao J, Lee JH, Kim SE, Kim SC, Chung KY, Roh MR. Zheng Z, et al. Yonsei Med J. 2015 Mar;56(2):440-6. doi: 10.3349/ymj.2015.56.2.440. Yonsei Med J. 2015. PMID: 25683993 Free PMC article.
-
Imatinib in the treatment of dermatofibrosarcoma protuberans.
Labropoulos SV, Razis ED. Labropoulos SV, et al. Biologics. 2007 Dec;1(4):347-53. Biologics. 2007. PMID: 19707305 Free PMC article.
-
Dermatofibrosarcoma protuberans treated by micrographic surgery.
Ah-Weng A, Marsden JR, Sanders DS, Waters R. Ah-Weng A, et al. Br J Cancer. 2002 Dec 2;87(12):1386-9. doi: 10.1038/sj.bjc.6600643. Br J Cancer. 2002. PMID: 12454766 Free PMC article. Review.
-
Dermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck.
Angouridakis N, Kafas P, Jerjes W, Triaridis S, Upile T, Karkavelas G, Nikolaou A. Angouridakis N, et al. Head Neck Oncol. 2011 Feb 4;3:5. doi: 10.1186/1758-3284-3-5. Head Neck Oncol. 2011. PMID: 21294902 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Medical
Research Materials