Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators - PubMed

Review

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators

Andreas Ritzén et al. Basic Clin Pharmacol Toxicol. 2005 Oct.

Free article

Abstract

The metabotropic glutamate receptors (mGluR) consist of a family of eight G-protein-coupled receptors that differ in their function, distribution and physiological roles within the central nervous system. In recent years substantial efforts have been made towards developing selective agonists and antagonists which have proven useful for elucidating their potential as novel targets for the treatment of psychiatric and neurological diseases. In the present review we will provide an update of the recent developments of functional allosteric modulators of the mGluR family and explore their therapeutic potential for anxiety/depression, schizophrenia, epilepsy/stroke, pain and Alzheimer's, Parkinson's and Huntington's diseases.

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