Regulation of the p53 transcriptional activity - PubMed
- ️Sun Jan 01 2006
Review
. 2006 Feb 15;97(3):448-58.
doi: 10.1002/jcb.20700.
Affiliations
- PMID: 16288459
- DOI: 10.1002/jcb.20700
Review
Regulation of the p53 transcriptional activity
Gang Liu et al. J Cell Biochem. 2006.
Abstract
In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co-activators, and co-repressors involved in p53-dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field.
(c) 2005 Wiley-Liss, Inc.
Similar articles
-
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
Hublitz P, Kunowska N, Mayer UP, Müller JM, Heyne K, Yin N, Fritzsche C, Poli C, Miguet L, Schupp IW, van Grunsven LA, Potiers N, van Dorsselaer A, Metzger E, Roemer K, Schüle R. Hublitz P, et al. Genes Dev. 2005 Dec 1;19(23):2912-24. doi: 10.1101/gad.351205. Genes Dev. 2005. PMID: 16322561 Free PMC article.
-
Transcriptional regulation by p53: one protein, many possibilities.
Laptenko O, Prives C. Laptenko O, et al. Cell Death Differ. 2006 Jun;13(6):951-61. doi: 10.1038/sj.cdd.4401916. Cell Death Differ. 2006. PMID: 16575405 Review.
-
Methods to study p53-repressed promoters.
Dumont P, Della Pietra A, Murphy ME. Dumont P, et al. Methods Mol Biol. 2003;234:111-20. doi: 10.1385/1-59259-408-5:111. Methods Mol Biol. 2003. PMID: 12824528
-
Transcriptional activities of mutant p53: when mutations are more than a loss.
Kim E, Deppert W. Kim E, et al. J Cell Biochem. 2004 Nov 15;93(5):878-86. doi: 10.1002/jcb.20271. J Cell Biochem. 2004. PMID: 15449312 Review.
-
Li J, Liu Y, Dai JZ, Xu DP, Zhang LX. Li J, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006 Mar;20(1):26-9. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006. PMID: 16642213 Chinese.
Cited by
-
Sun CM, Huang SF, Zeng JM, Liu DB, Xiao Q, Tian WJ, Zhu XD, Huang ZG, Feng WL. Sun CM, et al. Pathol Oncol Res. 2010 Sep;16(3):403-11. doi: 10.1007/s12253-009-9227-0. Epub 2009 Dec 3. Pathol Oncol Res. 2010. PMID: 19957060
-
p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2.
Kumar A, Kim CS, Hoffman TA, Naqvi A, Dericco J, Jung SB, Lin Z, Jain MK, Irani K. Kumar A, et al. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):133-41. doi: 10.1161/ATVBAHA.110.215061. Epub 2010 Oct 14. Arterioscler Thromb Vasc Biol. 2011. PMID: 20947822 Free PMC article.
-
Yang R, Yang H, Wei J, Li W, Yue F, Song Y, He X, Hu K. Yang R, et al. Front Pharmacol. 2021 Oct 14;12:717652. doi: 10.3389/fphar.2021.717652. eCollection 2021. Front Pharmacol. 2021. PMID: 34721017 Free PMC article.
-
TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
Li H, Fang H, Chang L, Qiu S, Ren X, Cao L, Bian J, Wang Z, Guo Y, Lv J, Sun Z, Wang T, Li B. Li H, et al. Front Immunol. 2021 Dec 2;12:764749. doi: 10.3389/fimmu.2021.764749. eCollection 2021. Front Immunol. 2021. PMID: 34925334 Free PMC article. Review.
-
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.
Dai C, Tang Y, Jung SY, Qin J, Aaronson SA, Gu W. Dai C, et al. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18937-42. doi: 10.1073/pnas.1110988108. Epub 2011 Nov 14. Proc Natl Acad Sci U S A. 2011. PMID: 22084066 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous