Chromatin, transcript elongation and alternative splicing - PubMed
Comment
Chromatin, transcript elongation and alternative splicing
Alberto R Kornblihtt. Nat Struct Mol Biol. 2006 Jan.
Abstract
A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.
Comment on
-
The human SWI/SNF subunit Brm is a regulator of alternative splicing.
Batsché E, Yaniv M, Muchardt C. Batsché E, et al. Nat Struct Mol Biol. 2006 Jan;13(1):22-9. doi: 10.1038/nsmb1030. Epub 2005 Dec 11. Nat Struct Mol Biol. 2006. PMID: 16341228
Similar articles
-
The human SWI/SNF subunit Brm is a regulator of alternative splicing.
Batsché E, Yaniv M, Muchardt C. Batsché E, et al. Nat Struct Mol Biol. 2006 Jan;13(1):22-9. doi: 10.1038/nsmb1030. Epub 2005 Dec 11. Nat Struct Mol Biol. 2006. PMID: 16341228
-
Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better.
Nogués G, Kadener S, Cramer P, de la Mata M, Fededa JP, Blaustein M, Srebrow A, Kornblihtt AR. Nogués G, et al. IUBMB Life. 2003 Apr-May;55(4-5):235-41. doi: 10.1080/1521654031000119830. IUBMB Life. 2003. PMID: 12880204 Review.
-
Splicing, transcription, and chromatin: a ménage à trois.
Allemand E, Batsché E, Muchardt C. Allemand E, et al. Curr Opin Genet Dev. 2008 Apr;18(2):145-51. doi: 10.1016/j.gde.2008.01.006. Epub 2008 Mar 26. Curr Opin Genet Dev. 2008. PMID: 18372167 Review.
-
Emerging role for transcript elongation in plant development.
Grasser KD. Grasser KD. Trends Plant Sci. 2005 Oct;10(10):484-90. doi: 10.1016/j.tplants.2005.08.004. Trends Plant Sci. 2005. PMID: 16150628 Review.
-
Co-transcriptional regulation of alternative pre-mRNA splicing.
Shukla S, Oberdoerffer S. Shukla S, et al. Biochim Biophys Acta. 2012 Jul;1819(7):673-83. doi: 10.1016/j.bbagrm.2012.01.014. Epub 2012 Feb 2. Biochim Biophys Acta. 2012. PMID: 22326677 Free PMC article. Review.
Cited by
-
Broad regulation of gene isoform expression by Wnt signaling in cancer.
Idris M, Harmston N, Petretto E, Madan B, Virshup DM. Idris M, et al. RNA. 2019 Dec;25(12):1696-1713. doi: 10.1261/rna.071506.119. Epub 2019 Sep 10. RNA. 2019. PMID: 31506381 Free PMC article.
-
Li H, Rodriguez J, Yoo Y, Shareef MM, Badugu R, Horabin JI, Kellum R. Li H, et al. PLoS Genet. 2011 Jun;7(6):e1002122. doi: 10.1371/journal.pgen.1002122. Epub 2011 Jun 9. PLoS Genet. 2011. PMID: 21695246 Free PMC article.
-
Alternative promoters influence alternative splicing at the genomic level.
Xin D, Hu L, Kong X. Xin D, et al. PLoS One. 2008 Jun 18;3(6):e2377. doi: 10.1371/journal.pone.0002377. PLoS One. 2008. PMID: 18560582 Free PMC article.
-
Widespread RNA binding by chromatin-associated proteins.
G Hendrickson D, Kelley DR, Tenen D, Bernstein B, Rinn JL. G Hendrickson D, et al. Genome Biol. 2016 Feb 16;17:28. doi: 10.1186/s13059-016-0878-3. Genome Biol. 2016. PMID: 26883116 Free PMC article.
-
Mediator complex regulates alternative mRNA processing via the MED23 subunit.
Huang Y, Li W, Yao X, Lin QJ, Yin JW, Liang Y, Heiner M, Tian B, Hui J, Wang G. Huang Y, et al. Mol Cell. 2012 Feb 24;45(4):459-69. doi: 10.1016/j.molcel.2011.12.022. Epub 2012 Jan 19. Mol Cell. 2012. PMID: 22264826 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources