Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 - PubMed

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• PMID: 16408017
• DOI: 10.1038/nchembio721

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Dorothea Greiner et al. Nat Chem Biol. 2005 Aug.

Abstract

Histone methylation plays a key role in establishing and maintaining stable gene expression patterns during cellular differentiation and embryonic development. Here, we report the characterization of the fungal metabolite chaetocin as the first inhibitor of a lysine-specific histone methyltransferase. Chaetocin is specific for the methyltransferase SU(VAR)3-9 both in vitro and in vivo and may therefore be used to study heterochromatin-mediated gene repression.

Comment in

• Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

  Cherblanc FL, Chapman KL, Brown R, Fuchter MJ. Cherblanc FL, et al. Nat Chem Biol. 2013 Mar;9(3):136-7. doi: 10.1038/nchembio.1187. Nat Chem Biol. 2013. PMID: 23416387 No abstract available.

• Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".

  Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A. Greiner D, et al. Nat Chem Biol. 2013 Mar;9(3):137. doi: 10.1038/nchembio.1188. Nat Chem Biol. 2013. PMID: 23416388 No abstract available.

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• Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".

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